Evidence map›Paper›PMID 33168699›Full record

ArticleMolecular and cellular biology2021

Sirtuin 5 Is Regulated by the SCF

Christine A Mills, Xianxi Wang, Dhaval P Bhatt, Paul A Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J Burke, Jeanette Gowen Cook, Matthew D Hirschey, Michael J Emanuele

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Differential genomic effects of four nano-sized and one micro-sized CeOMaterials express : an international journal on multidisciplinary materials research · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christine A MillsDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Xianxi WangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Dhaval P BhattDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Paul A GrimsrudDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Jacob Peter MatsonDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Debojyoti LahiriDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Daniel J BurkeDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Jeanette Gowen CookLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Matthew D HirscheyDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA matthew.hirschey@duke.edu emanuele@email.unc.edu.
Michael J EmanueleLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA matthew.hirschey@duke.edu emanuele@email.unc.edu.ORCID 0000-0003-4104-7449
Duke University · USUniversity of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC Initiative for Maximizing Student DevelopmentR25GM055336 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN, KASH, THOMAS L. · 1996 to 2023
$12.1M
Studies on the Mechanisms by which SIRT5 Regulates Aging and DiseaseR01AG045351 · NIA · DUKE UNIVERSITY · PI HIRSCHEY, MATTHEW D · 2014 to 2023
$4.4M
DUKE TRAINING GRANT IN NEPHROLOGYT32DK007731 · NIDDK · DUKE UNIVERSITY · PI CROWLEY, STEVEN D · 1995 to 2021
$3.6M
Replication Licensing and the Cell CycleR01GM083024 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN · 2009 to 2020
$2.9M
Post-Translational Regulation of DNA Replication Origin Licensing in Human CellsR01GM102413 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN · 2013 to 2021
$2.5M
SCF Ubiquitin Ligases in Cell Cycle Control and Chromosome StabilityR01GM120309 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EMANUELE, MICHAEL JAMES · 2016 to 2023
$2.3M
Deubiquitinases in Cell Cycle ControlR01GM134231 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EMANUELE, MICHAEL JAMES · 2020 to 2023
$1.6M
NCI NIH HHS P30 CA016086NIA NIH HHS R01 AG045351NIDDK NIH HHS T32 DK007731NIGMS NIH HHS R01 GM083024NIGMS NIH HHS R01 GM102413NIGMS NIH HHS R01 GM120309NIGMS NIH HHS R01 GM134231NIGMS NIH HHS R25 GM055336
6 · The paper itself

Abstract

The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the

Indexed as

Gene Expression Regulation, FungalProtein Processing, Post-TranslationalCell CycleCell Cycle ProteinsF-Box ProteinsGene Expression ProfilingGenes, LethalHEK293 CellsHeLa CellsHumansMutationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionSirtuinsSKP Cullin F-Box Protein LigasesCDC4 protein, S cerevisiaeCell Cycle ProteinsF-Box ProteinsSaccharomyces cerevisiae ProteinsSirtuinsSKP Cullin F-Box Protein LigasesUbiquitin-Protein Ligasescell cyclecyclin F (CCNF)metabolismSCFsirtuin 5 (SIRT5)ubiquitin

Identifiers

PMID33168699
PMCPMC8093487
OpenAlexW3098374335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.