Evidence map›Paper›PMID 33168618›Full record

ArticleeNeuro

Excessive Formation and Stabilization of Dendritic Spine Clusters in the

Ryan Thomas Ash, Jiyoung Park, Bernhard Suter, Huda Yaya Zoghbi, Stelios Manolis Smirnakis

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Review
  11. Rett Syndrome andNeuropsychiatric disease and treatment · 2022
    Review
  12. mTOR-Dependent Spine Dynamics in Autism.Frontiers in molecular neuroscience · 2022
    Review
  13. International journal of molecular sciences · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryan Thomas AshDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.
Jiyoung ParkDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Bernhard SuterDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Huda Yaya ZoghbiDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-0700-3349
Stelios Manolis SmirnakisDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030 smsmirnakis@bwh.harvard.edu.ORCID 0000-0002-1929-2811
Brigham and Women's Hospital · USHoward Hughes Medical Institute · US

Funding

MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5M
6 · The paper itself

Abstract

Autism-associated genetic mutations may perturb the balance between stability and plasticity of synaptic connections in the brain. Here, we report an increase in the formation and stabilization of dendritic spines in the cerebral cortex of the mouse model of

Indexed as

Autistic DisorderX-Linked Intellectual DisabilityAnimalsCerebral CortexDendritic SpinesDisease Models, AnimalMethyl-CpG-Binding Protein 2MiceMecp2 protein, mouseMethyl-CpG-Binding Protein 2autismdendritic spineMECP2motor cortexneuroplasticitystructural plasticity

Identifiers

PMID33168618
PMCPMC7877475
OpenAlexW3102023124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.