Evidence map›Paper›PMID 33168592›Full record

ArticleBiology open2020

Assessing methods to quantitatively validate TGFβ-dependent autophagy.

Charles B Trelford, Gianni M Di Guglielmo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Regulation of TGF-Cancers · 2022
    Article
  4. Review
  5. Transforming growth factor-β in tumour development.Frontiers in molecular biosciences · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Charles B TrelfordSchulich School of Medicine and Dentistry, Western University, Department of Physiology and Pharmacology, London, Ontario, Canada N6A 5B7.
Gianni M Di GuglielmoSchulich School of Medicine and Dentistry, Western University, Department of Physiology and Pharmacology, London, Ontario, Canada N6A 5B7 john.diguglielmo@schulich.uwo.ca.ORCID 0000-0002-2439-2737
Western University · CA

Funding

CIHR MOP-93625
6 · The paper itself

Abstract

Transforming growth factor beta (TGFβ) promotes tumorigenesis by suppressing immune surveillance and inducing epithelial to mesenchymal transition (EMT). TGFβ may augment tumorigenesis by activating autophagy, which protects cancer cells from chemotherapy and promotes invasive and anti-apoptotic properties. Here, we assess how TGFβ1 modulates autophagy related (

Indexed as

AutophagyAutophagosomesAutophagy-Related ProteinsBiomarkersCarcinoma, Non-Small-Cell LungCell Line, TumorFluorescent Antibody TechniqueHumansLung NeoplasmsLysosomesMicrotubule-Associated ProteinsTransforming Growth Factor betaTransforming Growth Factor beta1Autophagy-Related ProteinsBiomarkersMAP1LC3B protein, humanMicrotubule-Associated ProteinsTGFB1 protein, humanTransforming Growth Factor betaTransforming Growth Factor beta1Autophagic fluxAutophagyMicrotubule-associated protein light chain 3B (LC3B)Non-small cell lung cancer (NSCLC) and Transforming growth factor beta (TGFβ)

Identifiers

PMID33168592
PMCPMC7710024
OpenAlexW3101257218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.