ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018
[ole of AGGF1 in DNA damage repair and modulating chemotherapy resistance in human colon cancer cells
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors at 2 institutions in 1 country.
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Abstract
objectiveTo investigate the role of AGGF1 in DNA damage repair and modulating chemotherapy resistance in human colon cancer cells.
methodsCisplatin-induced human colon cancer HCT116 cells transfected with AGGF1 siRNA and siNC
resultsWestern blotting showed that AGGF1 expression was significantly down-regulated in HCT116 cells after cisplatin exposure, and transfection withAGGF1 siRNAobviously inhibited the expression of phosphorylated γH2AX and NBS1. Immunofluorescence assay showed the co-localization of AGGF1 and γH2AX. Down-regulation of AGGF1 mediated by siRNA obviously increased the chemosensitivity of the cells (
conclusionsDown-regulation of AGGF1 inhibits DNA damage repair and increases the chemosensitivity in colon cancer cells possibly in relation with the suppressed phosphorylation of NBS1.
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