Evidence map›Paper›PMID 33168339›Full record

ArticleDrug and alcohol dependence2021

Alexithymia and pain experience among patients using methadone-maintenance therapy.

Kristen P Morie, Marc N Potenza, Mark Beitel, Lindsay M Oberleitner, Corey R Roos, Sarah W Yip, David E Oberleitner, Marina Gaeta, Declan T Barry

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kristen P MorieDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: Kristen.morie@yale.edu.
Marc N PotenzaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA; Connecticut Council on Problem Gambling, Wethersfield, CT, USA; Department of Neuroscience, Yale University, New Haven, CT, USA.
Mark BeitelDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; Pain Treatment Services, APT Foundation, Inc, New Haven, CT, USA.
Lindsay M OberleitnerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Psychology, Western Connecticut State University, Danbury, CT, USA.
Corey R RoosDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Sarah W YipDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA.
David E OberleitnerDepartment of Psychology, University of Bridgeport, Bridgeport, CT, USA.
Marina GaetaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Pain Treatment Services, APT Foundation, Inc, New Haven, CT, USA.
Declan T BarryDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA; Pain Treatment Services, APT Foundation, Inc, New Haven, CT, USA.
Yale University · USAPT Foundation · USConnecticut Mental Health Center · USUniversity of Bridgeport · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Training Fellowship in Substance use and Addiction (RTFSA)T32DA007238 · NIDA · YALE UNIVERSITY · PI BRIAN D. KILUK, ISMENE L. PETRAKIS · 1988 to 2026
$5.7M
Development of Reward Processing in prenatally exposed adolescents and young adultsK01DA042937 · NIDA · YALE UNIVERSITY · PI MORIE, KRISTEN PAULA · 2017 to 2021
$907k
Neural mechanisms of galantamine treatment for cocaine dependenceK01DA039299 · NIDA · YALE UNIVERSITY · PI YIP, SARAH · 2016 to 2020
$905k
Chronic Pain and Opioid Dependence Assessment and TreatmentK23DA024050 · NIDA · YALE UNIVERSITY · PI BARRY, DECLAN T. · 2008 to 2012
$901k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K01 DA039299NIDA NIH HHS K01 DA042937NIDA NIH HHS K23 DA024050NIDA NIH HHS T32 DA007238
6 · The paper itself

Abstract

backgroundAlexithymia, difficulty identifying and describing one's emotions coupled with a tendency to externalize, is a potentially important yet understudied treatment target for patients with opioid use disorder. The aim of this study was to examine the role of alexithymia in pain experience among individuals with opioid use disorder.

methodsOne-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences. Comparisons were performed on the full sample between those with or without clinically significant levels of alexithymia. For a subsample reporting pain (n = 138), intercorrelations were performed to test whether drug use history, pain catastrophizing, pain acceptance, and alexithymia were related to pain severity and pain interference. Regression analyses were performed to test for serial mediation of pain catastrophizing and pain acceptance on the relationship between alexithymia and pain interference in this subsample.

resultsIndividuals with alexithymia showed increased pain catastrophizing and interference, and intercorrelations indicated that increased alexithymia was associated with increased pain interference, more pain catastrophizing, and reduced pain acceptance. A serial regression model among a subset of patients with pain indicated that pain catastrophizing and pain acceptance mediated the effect of alexithymia on pain interference.

conclusionsThese findings suggest that alexithymia, as well as both pain catastrophizing and pain acceptance, contribute to interference associated with pain and are potentially important intervention targets among methadone-treated patients with pain.

Indexed as

Opiate Substitution TreatmentAdultAffective SymptomsCatastrophizationEmotionsHumansMaleMethadoneMiddle AgedPainPain MeasurementSelf ReportMethadoneAlexithymiaMethadoneOpioid use disorderPain

Identifiers

PMID33168339
PMCPMC8103623
OpenAlexW3094018981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.