ArticleZeitschrift fur medizinische Physik2022
Dosimetric impact of geometric distortions in an MRI-only proton therapy workflow for lung, liver and pancreas.
Article in Zeitschrift fur medizinische Physik, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Synthetic CT imaging for pelvic and abdominal MR-only radiotherapy: Clinical validation on a 1.5T MR-Linac.Journal of applied clinical medical physics · 2026Article
- Generation of multimodal realistic computational phantoms as a test-bed for validating deep learning-based cross-modality synthesis techniques.Medical & biological engineering & computing · 2026Article
- Quality assurance and temporal stability of a 1.5 T MRI scanner for MR-guided Photon and Particle Therapy.Zeitschrift fur medizinische Physik · 2025Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a radiation therapy workflow based on Magnetic Resonance Imaging (MRI), dosimetric errors may arise due to geometric distortions introduced by MRI. The aim of this study was to quantify the dosimetric effect of system-dependent geometric distortions in an MRI-only workflow for proton therapy applied at extra-cranial sites. An approach was developed, in which computed tomography (CT) images were distorted using an MRI displacement map, which represented the MR distortions in a spoiled gradient-echo sequence due to gradient nonlinearities and static magnetic field inhomogeneities. A retrospective study was conducted on 4DCT/MRI digital phantoms and 18 4DCT clinical datasets of the thoraco-abdominal site. The treatment plans were designed and separately optimized for each beam in a beam specific Planning Target Volume on the distorted CT, and the final dose distribution was obtained as the average. The dose was then recalculated in undistorted CT using the same beam geometry and beam weights. The analysis was performed in terms of Dose Volume Histogram (DVH) parameters. No clinically relevant dosimetric impact was observed on organs at risk, whereas in the target structure, geometric distortions caused statistically significant variations in the planned dose DVH parameters and dose homogeneity index (DHI). The dosimetric variations in the target structure were smaller in abdominal cases (ΔD
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