ArticleComparative medicine2020
Effect of Xylazine-Tiletamine-Zolazepam on the Local Field Potential of the Rat Olfactory Bulb.
Article in Comparative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Profiling and Identification of Novel Tiletamine Metabolites in Human Urine and Hair by Liquid Chromatography Coupled With Quadrupole-Orbitrap Mass Spectrometry.Rapid communications in mass spectrometry : RCM · 2026Article
- Improved Recovery of Complete Spinal Cord Transection by a Plasma-Modified Fibrillar Scaffold.Polymers · 2024Article
- An Experimental Model of Proton-Beam-Induced Radiation Dermatitis In Vivo.International journal of molecular sciences · 2023Article
- Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia.IBRO neuroscience reports · 2022Article
- Intraocular pressure and cardiovascular effects of dexmedetomidine premedication and tiletamine-zolazepam for anesthetic induction in dogs.Veterinary world · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural oscillations of the mammalian olfactory system have been studied for decades. This research suggests they are linked to various processes involved in odor information analysis, depending on the vigilance state and presentation of stimuli. In addition, the effects of various anesthetics, including commonly used ones like chloral hydrate, pentobarbital, ketamine, and urethane, on the local field potential (LFP) in the olfactory bulb (OB) have been studied. In particular, the combination of xylazine and tiletamine-zolazepam has been shown to produce steady anesthesia for an extended period and relatively few adverse effects; however, their effects on the LFP in the OB remain unknown. To study those effects, we recorded the LFP in the OB of rats under xylazine-tiletamine-zolazepam anesthesia. During the period of anesthesia, the spectral powers of the 1-4, 9-16, 31-64, 65-90 frequency bands increased significantly, and that of 91-170 Hz frequency band decreased significantly, whereas no significant changes were observed in the 5-8 and 17-30 Hz ranges. These results reveal dynamic changes in the time and frequency characteristics of the LFP in the OB of rats under xylazine-tiletamine- zolazepam anesthesia and suggest that this combination of anesthetics could be used for studying oscillatory processes in the OB of rats.
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Registered trials
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