Evidence map›Paper›PMID 33168093›Full record

ArticleAntimicrobial resistance and infection control2020

Artemether-lumefantrin treatment adherence among uncomplicated plasmodium falciparum malaria patients, visiting public health facilities in AsgedeTsimbla district, Tigray, Ethiopia: a cross-sectional study.

Mekonnen Gebremichael Gebrekidan, Gebretsadik Berhe Gebremedhin, Yosef Sibhatu Gebregiorgis, Alefech Addisu Gezehegn, Kissanet Tesfay Weldearegay

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Article in Antimicrobial resistance and infection control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mekonnen Gebremichael GebrekidanTigray Regional Health Bureau, Mekelle, Tigray, Ethiopia.
Gebretsadik Berhe GebremedhinCollege of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle University, Mekelle, Tigray, Ethiopia.
Yosef Sibhatu GebregiorgisCollege of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle University, Mekelle, Tigray, Ethiopia. yosefsibhatu@gmail.com.
Alefech Addisu GezehegnFederal Ministry of Health, Mekelle, Tigray, Ethiopia.
Kissanet Tesfay WeldearegayCollege of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle University, Mekelle, Tigray, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEthiopia has set a goal to eliminate malaria by 2030; Artemether-lumefantrine (AL) is put as one of the cornerstone strategies for uncomplicated plasmodium falciparum malaria treatment. However, only focusing on prescribing of the treatment without assessing patients' adherence could lead to the resistance of the drug. In Ethiopia, there is limited evidence about patients' adherence to AL and its influencing factors. Therefore, this study aimed at addressing this information gap.

methodsA health facility based cross-sectional study was employed. Participants were selected using simple random sampling technique from registration books of the public health facilities in AsgedeTsimbla. Data were collected from March 24th to April 30th, 2018. We interviewed participants using a pre-tested structured questionnaire, and the blister pack was also inspected at their homes on day 4. Data were entered into Epi-Info and analyzed using SPSS 21. Odds ratios with 95% Confidence Intervals were estimated and the level of significance was declared at p-value ≤ 0.05.

resultsA total of 384 study participants were interviewed with a response rate of 95.5%. The overall AL adherence was 53.6% (95% CI 48.4-58.3%). Children aged < 5 years [AOR: 0.4, 95% CI (0.2-0.8)], and being treated in health post [AOR: 0.3, 95% CI (0.1-0.5)] were more likely to show AL adherence whereas illiteracy [AOR: 9.4, 95% CI (4.2-21.3)], didn't know the consequence of discontinued AL [AOR: 4.0, 95% CI (2.1-7.6)], had concomitant drugs [AOR: 2.5, 95% CI (1.4-4.5)], and stopped/saved drug when improved before tablet got finished [AOR: 3.2, 95% CI (1.7-5.9)] were factors less likely to be associated with AL adherence.

conclusionAL adherence was low. Children aged < 5 years, and being treated in health post were determinants of AL adherence whereas illiteracy, didn't know the consequence of discontinued the drug, had concomitant drugs, and stopped/saved drug when improved before tablet got finished were factors that hindered the AL adherence. Stakeholders should emphasize designing appropriate strategies including educational interventions to increase the AL adherence and prevent drug resistance. Further research should be conducted to evaluate AL resistance.

Indexed as

Medication AdherenceAdolescentAdultAgedAntimalarialsArtemether, Lumefantrine Drug CombinationChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantMalaria, FalciparumMaleMiddle AgedPublic HealthAntimalarialsArtemether, Lumefantrine Drug CombinationAdherenceArtemether–lumefantrinePlasmodium falciparum

Identifiers

PMID33168093
PMCPMC7653737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.