ArticleParasites & vectors2020
Molecular basis of resistance to organophosphate insecticides in the New World screw-worm fly.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Of cattle and humans: A narrative review on the re-emergence of the New World screwworm (Cochliomyia hominivorax) and its threat to human health.PLoS neglected tropical diseases · 2026Review
- Transcriptomic insights into the effects of monocrotophos on Chrysomya megacephala: forensic implications of altered pupation time.Molecular biology reports · 2025Article
- Demographic and historical processes influencing Cochliomyia hominivorax (Diptera: Calliphoridae) population structure across South America.Parasites & vectors · 2025Article
- Comparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin.Electrophoresis · 2025Article
- Morphological and Molecular Characterizations ofDiagnostics (Basel, Switzerland) · 2023Article
- A chromosomal-scale reference genome of the New World Screwworm, Cochliomyia hominivorax.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe emergence of insecticide resistance is a fast-paced example of the evolutionary process of natural selection. In this study, we investigated the molecular basis of resistance in the myiasis-causing fly Cochliomyia hominivorax (Diptera: Calliphoridae) to dimethyl-organophosphate (OP) insecticides.
methodsBy sequencing the RNA from surviving larvae treated with dimethyl-OP (resistant condition) and non-treated larvae (control condition), we identified genes displaying condition-specific polymorphisms, as well as those differentially expressed.
resultsBoth analyses revealed that resistant individuals have altered expression and allele-specific expression of genes involved in proteolysis (specifically serine-endopeptidase), olfactory perception and cuticle metabolism, among others. We also confirmed that resistant individuals carry almost invariably the Trp251Ser mutation in the esterase E3, known to confer OP and Pyrethroid resistance. Interestingly, genes involved in metabolic and detoxifying processes (notably cytochrome P450s) were found under-expressed in resistant individuals. An exception to this were esterases, which were found up-regulated.
conclusionsThese observations suggest that reduced penetration and aversion to dimethyl-OP contaminated food may be important complementary strategies of resistant individuals. The specific genes and processes found are an important starting point for future functional studies. Their role in insecticide resistance merits consideration to better the current pest management strategies.
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