ArticleGenome biology2020
Massive gene presence-absence variation shapes an open pan-genome in the Mediterranean mussel.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed.
- Mussel Spermatozoa Express a Specific Isoform of the Catalytic Subunit of cAMP-Dependent Protein Kinase.Molecular reproduction and development · 2026Article
- The Pan-Genome of 1107 Spotted Sea Bass Accessions Reveals Gene Evolution Patterns During Domestication Selection.Molecular ecology resources · 2026Article
- Comparative Genomics ofEcology and evolution · 2026Article
- Expression of Mono- and Dimeric Ganglioside-Binding Lectins and Their Cellular Functions.Methods in molecular biology (Clifton, N.J.) · 2026Article
- External immune sentinels in the seawater ecosystem: the specialization of bivalve hemocytes.Frontiers in immunology · 2026Article
- From few to many: How non-model organisms' genomics broadened our understanding of molecular evolution.Genetics and molecular biology · 2026Article
- Independent divergences of the aquaporins across different genera highlight the distinct adaptation mechanisms within Mytilida.BMC genomics · 2025Article
- Population Genomics and Connectivity of the Blue Mussel Species Complex: Insights From a North-East Atlantic Hybrid Zone.Evolutionary applications · 2025Article
- From fragmentation to resolution: high-fidelity genome assembly of zancudomyces culisetae through comparative insights from PacBio, Nanopore, and Illumina sequencing.G3 (Bethesda, Md.) · 2025Article
- Comparative Transcriptomics Provides Insight into the Neuroendocrine Regulation of Spawning in the Black-Lip Rock Oyster (International journal of molecular sciences · 2025Article
- Comparative Genomics of Sex-Determination-Related Genes Reveals Shared Evolutionary Patterns Between Bivalves and Mammals, but Not Fruit Flies.Molecular ecology · 2025Article
- The highly dynamic pangenome of basal chordates is enriched in defence and immunity genes and is inherited following the Mendelian law.PLoS genetics · 2025Article
- Ancestral Origin and Functional Expression of a Hyaluronic Acid Pathway Complement in Mussels.Biology · 2025Article
- Tracing the Evolutionary Expansion of a Hyperdiverse Antimicrobial Peptide Gene Family inGenes · 2025Article
- Small-scale habitat heterogeneity and genotype modulate in situ gene expression of the Antarctic bivalve Aequiyoldia eightsii in front of a melting glacier.BMC ecology and evolution · 2025Article
- Weak genetic divergence and signals of adaptation obscured by high gene flow in an economically important aquaculture species.BMC genomics · 2025Article
- Is the extreme within-population genome size variation real in Spodoptera frugiperda?PloS one · 2025Article
- Anthropogenic noise exposure suppresses the immune response inFrontiers in immunology · 2025Article
- Dynamics ofFrontiers in immunology · 2025Article
- Pangenome graphs and their applications in biodiversity genomics.Nature genetics · 2025Review
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Mediterranean mussel Mytilus galloprovincialis is an ecologically and economically relevant edible marine bivalve, highly invasive and resilient to biotic and abiotic stressors causing recurrent massive mortalities in other bivalves. Although these traits have been recently linked with the maintenance of a high genetic variation within natural populations, the factors underlying the evolutionary success of this species remain unclear.
resultsHere, after the assembly of a 1.28-Gb reference genome and the resequencing of 14 individuals from two independent populations, we reveal a complex pan-genomic architecture in M. galloprovincialis, with a core set of 45,000 genes plus a strikingly high number of dispensable genes (20,000) subject to presence-absence variation, which may be entirely missing in several individuals. We show that dispensable genes are associated with hemizygous genomic regions affected by structural variants, which overall account for nearly 580 Mb of DNA sequence not included in the reference genome assembly. As such, this is the first study to report the widespread occurrence of gene presence-absence variation at a whole-genome scale in the animal kingdom.
conclusionsDispensable genes usually belong to young and recently expanded gene families enriched in survival functions, which might be the key to explain the resilience and invasiveness of this species. This unique pan-genome architecture is characterized by dispensable genes in accessory genomic regions that exceed by orders of magnitude those observed in other metazoans, including humans, and closely mirror the open pan-genomes found in prokaryotes and in a few non-metazoan eukaryotes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.