SynthesisReproductive biology and endocrinology : RB&E2020
Evaluation of treatment of previous cesarean scar pregnancy with methotrexate: a systematic review and meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Advances in Treating Cesarean Scar Pregnancy: A Comprehensive Review of Techniques, Clinical Outcomes, and Fertility Preservation.Medical science monitor : international medical journal of experimental and clinical research · 2024Pooled it
- Chinese herbal medicine for threatened miscarriage: An updated systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Exclusive hysteroscopic approach for the treatment of cesarean scar pregnancy: Systematic review of the literature.Women's health (London, England)Pooled it
- The Role of Interventional Radiology in the Diagnosis and Treatment of Gynecological Conditions.Tomography (Ann Arbor, Mich.) · 2026Review
- Cesarean Scar Pregnancy Diagnosed in the First Trimester: A Report of Two Cases and Literature Review.Cureus · 2026Article
- Surgical treatment of cesarean scar pregnancy based on the three-category system: a retrospective analysis.BMC pregnancy and childbirth · 2024Article
- Systematic evaluation of the efficacy of treatments for cesarean scar pregnancy.Reproductive biology and endocrinology : RB&E · 2024Article
- Scarred for life: a review of cesarean section scar pregnancy and potential pitfalls in diagnosis.Abdominal radiology (New York) · 2023Review
- [Treatment of ectopic pregnancy implanted on cesarea scar: cohort study 2018-2022, Lima, Peru].Revista colombiana de obstetricia y ginecologia · 2023Article
- Comparing the clinical efficacy of three surgical methods for cesarean scar pregnancy.BMC women's health · 2023Article
- Treatment of Cesarean Scar Ectopic Pregnancy in China with Uterine Artery Embolization-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Conservative Management of Cesarean Scar Pregnancy: A Case Report and Literature Review.Case reports in obstetrics and gynecology · 2022Article
- Local Methotrexate Injection Followed by Dilation and Curettage for Cesarean Scar Pregnancy: A Prospective Non-randomized Study.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious caesarean scar pregnancy is one type of ectopic pregnancy in myometrium and fibrous tissue of previous caesarean scar. One of the therapeutic methods of this type of ectopic pregnancy is treatment with methotrexate. Given various findings on the treatment of caesarean scar pregnancy with methotrexate and lack of global report in this regard, we aimed to achieve a global report on the treatment of CSP with methotrexate through related literature review and analysis of the results of the studies, to enable more precise planning to reduce complications of CSP.
methodThis review study extracted information through searching national and international databases of SID،, Embase, ScienceDirect, ، Scopus, ، PubMed, Web of Science (ISI) between 2003 and January 2020. To perform the meta-analysis, random-effects model and heterogeneity of the studies with I
resultsIn total, 26 articles with a sample size of 600 individuals were enrolled in the meta-analysis. According to the results of the study, the mean level of β-hCG was 28,744.98 ± 4425.1 mIU/ml before the intervention and was 23,836.78 ± 4533.1 mIU/ml after the intervention. The mean intraoperative blood loss (ml) was 4.8 ± 3.76 ml, mean hospital stay (days) was 11.7 ± 1.2 days, mean time for serum-hCG normalization (days) was 41.6 ± 3.2 days, success was 90.7% (95% CI: 86.7-93.5%), and complication was 9% (95% CI: 6.3-12.8%).
conclusionThe results of the current study show methotrexate significantly reduces β-hCG levels and can be effective in treating caesarean scar pregnancy and its complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.