Evidence map›Paper›PMID 33167957›Full record

ArticleBMC oral health2020

Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction.

Narges Gholizadeh, Maryam Alipanahi Ramandi, Maziar Motiee-Langroudi, Mehrdad Jafari, Hadi Sharouny, Nafiseh Sheykhbahaei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  19. Evaluation of Serum and Salivary Lactate Dehydrogenase Levels in Patients with Oral Potentially Malignant Conditions/Lesions: A Clinical and Biochemical Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Narges GholizadehDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.
Maryam Alipanahi RamandiSchool of Dentistry, Tehran University of Medical Science, Tehran, Iran.
Maziar Motiee-LangroudiOtorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mehrdad JafariOtorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hadi SharounyOtorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nafiseh SheykhbahaeiDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran. dsheykhbahaei@gmail.com.
Tehran University of Medical Sciences · IRUniversity of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs.

methodsIn this case-control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson's correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data.

resultsThe serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH.

conclusionsPatients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsLichen Planus, OralMouth NeoplasmsCase-Control StudiesHumansL-Lactate DehydrogenaseSalivaSquamous Cell Carcinoma of Head and NeckL-Lactate DehydrogenaseCarcinomaLichenoid eruptionsLichen planusL-lactate dehydrogenaseOralSalivaSquamous cell

Identifiers

PMID33167957
PMCPMC7653894
OpenAlexW3104554413

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.