Evidence map›Paper›PMID 33167955›Full record

ArticleBMC pulmonary medicine2020

The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study.

Ling Sang, Sibei Chen, Xia Zheng, Weijie Guan, Zhihui Zhang, Wenhua Liang, Ming Zhong, Li Jiang, Chun Pan, Wei Zhang and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  11. COVID-19 Survival and its impact on chronic kidney disease.Translational research : the journal of laboratory and clinical medicine · 2022
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  19. Clinical features and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19): A multicenter cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 1 country.

Ling SangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Sibei ChenDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xia ZhengDepartment of Critical Care Medicine, The First Affiliated Hospital of Zhejiang University, Zhejiang, Hangzhou, China.
Weijie GuanDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhihui ZhangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenhua LiangDepartment of Thorax Surgery, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ming ZhongDepartment of Critical Care Medicine, Zhongshan Hospital Fudan University, Shanghai, China.
Li JiangDepartment of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chun PanDepartment of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, China.
Wei ZhangEmergency Department, the 900th Hospital of Joint Service Corps of Chinese PLA, FuZhou, China.
Jiaan XiaDepartment of tuberculosis, Wuhan Jinyintan Hospital, Wuhan, China.
Nanshan ChenDepartment of Respiratory and Critical Care Medicine, Wuhan Jinyintan Hospital, Wuhan, China.
Wenjuan WuDepartment of Critical Care Medicine, Wuhan Jinyintan Hospital, Wuhan, China.
Hongkai WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Yonghao XuDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xuesong LiuDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoqing LiuDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jianxing HeDepartment of Thorax Surgery, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shiyue LiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dingyu ZhangResearch Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, China.
Nanshan ZhongDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yimin LiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. dryiminli@vip.163.com.
First Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CNJinyintan Hospital · CN82th Hospital of Pla · CNCapital Medical University · CNFirst Affiliated Hospital Zhejiang University · CNWuhan Institute of Virology · CNZhongda Hospital Southeast University · CNZhongshan Hospital · CN

Funding

National Key Research and Development Program of China 2018YFC1200100National Natural Science Foundation of China 81970071National Natural Science Foundation of China 82070084Natural Science Foundation of Guangdong 2020A1515011459the National Science and Technology Major Project 2017ZX10204401the Special Project of Guangdong Science and Technology Department 2020B111105001
6 · The paper itself

Abstract

backgroundThe clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear.

methodsWe retrospectively reviewed medical records of all adult patients with laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 and April 6th 2020 at Wuhan JinYinTan Hospital and The First Affiliated Hospital of Guangzhou Medical University.

resultsAmong 210 patients, 131 were males (62.4%). The median Age was 64 years (IQR: 56-71). Of 92 (43.8%) patients who developed AKI during hospitalization, 13 (14.1%), 15 (16.3%) and 64 (69.6%) were classified as being at stage 1, 2 and 3, respectively. 54 patients (58.7%) received continuous renal replacement therapy. Age, sepsis, nephrotoxic drug, invasive mechanical ventilation and elevated baseline serum creatinine levels were associated with the occurrence of AKI. Renal recovery during hospitalization was identified among 16 patients with AKI (17.4%), who had a significantly shorter time from admission to AKI diagnosis, lower incidence of right heart failure and higher ratio of partial pressure of oxygen to the fraction of inspired oxygen. Of 210 patients, 93 deceased within 28 days of ICU admission. AKI stage 3, critical disease, greater Age and the lowest ratio of partial pressure of oxygen to the fraction of inspired oxygen being < 150 mmHg were independently associated with death.

conclusionsAmong patients with Covid-19, the incidence of AKI was high. Our findings of the risk factors of the development of AKI and factors associated with renal function recovery may inform clinical management of patients with critical illness of Covid-19.

Indexed as

BetacoronavirusAcute Kidney InjuryAdultAgedAged, 80 and overChinaCoronavirus InfectionsCOVID-19Critical IllnessFemaleHumansIncidenceMaleMiddle AgedPandemicsPneumonia, ViralAcute kidney injuryAcute respiratory distresCoronavirus disease 2019Intensive care unitMechanical ventilationSyndrome

Identifiers

PMID33167955
PMCPMC7649893
OpenAlexW3106419361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.