ArticleThe journal of headache and pain2020
Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Systematic review on the frequency of occurrence in nerve branches and the side of the face involved in trigeminal neuralgia and its clinical implication.Frontiers in neurology · 2024Pooled it
- The cerebrospinal fluid-contacting nucleus CGRP-RAMP1-PKA signaling pathway mediates trigeminal neuralgia and its mechanism.The Korean journal of pain · 2026Article
- Association of Transthyretin and Retinol-Binding Protein 4 With Risk of Classical Trigeminal Neuralgia: A Case-Control Study.Molecular neurobiology · 2026Article
- Clinical Characteristics and Early Pain Outcomes After Microvascular Decompression for Trigeminal Neuralgia: A Single-Center Retrospective Cohort Study.Brain sciences · 2026Article
- A mouse model of classical trigeminal neuralgia via intradural compression of the trigeminal nerve.The journal of headache and pain · 2025Article
- Hallmarks of primary headache: part 4 - rare headache syndromes.The journal of headache and pain · 2025Review
- Five-year prospective outcomes of medical management and microvascular decompression in trigeminal neuralgia.Journal of neurology · 2025Observational
- Radiosurgery to the Medial Thalamus for Chronic Pain: A Single Group Experience and Review of Literature.Cureus · 2025Article
- Gamma knife radiosurgery for benign tumor-related trigeminal neuralgia: a single-institution retrospective study.Neurosurgical review · 2025Article
- Pathogenesis, Diagnosis, and Management of Trigeminal Neuralgia: A Narrative Review.Journal of clinical medicine · 2025Review
- Emerging Psychotropic Drug for the Treatment of Trigeminal Pain: Salvinorin A.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Neuronavigated percutaneous gasserian radiofrequency thermorhizotomy for trigeminal neuralgia: how I do it.Acta neurochirurgica · 2024Article
- A cost effectiveness analysis of two treatment strategies for trigeminal neuralgia in Ontario.Surgical neurology international · 2024Article
- Article
- Neuropathic Pain in the Emergency Setting: Diagnosis and Management.Journal of clinical medicine · 2023Review
- Surgical and Clinical Outcomes of Microvascular Decompression: A Comparative Study between Young and Elderly Patients.Brain sciences · 2022Article
- Long term evaluation of a multidisciplinary trigeminal neuralgia service.The journal of headache and pain · 2022Article
- The Molecular Basis and Pathophysiology of Trigeminal Neuralgia.International journal of molecular sciences · 2022Review
- "They Could Have Cut My Head Off and I Wouldn't Have Cared"-A Qualitative Study of Patient Experiences and the Impact of Trigeminal Neuralgia.Journal of oral & facial pain and headache · 2022Article
- Trigeminal neuralgia: a practical guide.Practical neurology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.
methodsIn order to expand understanding of the pain-related burden of illness associated with TN, a cross-sectional survey was conducted of patients at a specialist center that utilizes a multidisciplinary care pathway. Participants provided information regarding their pain experience and treatment history, and completed several patient-reported outcome (PRO) measures.
resultsOf 129 respondents, 69/128 (54%; 1 missing) reported no pain in the past 4 weeks. However, 84 (65%) respondents were on medications, including 49 (38%) on monotherapy and 35 (27%) on polytherapy. A proportion of patients had discontinued at least one medication in the past, mostly due to lack of efficacy (n = 62, 48%) and side effects (n = 51, 40%). A total of 52 (40%) patients had undergone surgery, of whom 30 had microvascular decompression (MVD). Although surgery, especially MVD, provided satisfactory pain control in many patients, 29% of post-surgical patients reported complications, 19% had pain worsen or stay the same, 48% were still taking pain medications for TN, and 33% reported new and different facial pain.
conclusionsIn most PRO measures, respondents with current pain interference had poorer scores than those without pain interference. In the Patient Global Impression of Change, 79% expressed improvement since beginning of treatment at this clinic. These results indicate that while the multidisciplinary approach can substantially alleviate the impact of TN, there remains an unmet medical need for additional treatment options.
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