ArticleBMC genomics2020
Identification, evolution, expression, and docking studies of fatty acid desaturase genes in wheat (Triticum aestivum L.).
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 73 citations in OpenAlex.
- Genome-Wide Identification and Bioinformatics Analysis of theInternational journal of molecular sciences · 2026Article
- Genome-wide identification of the FAD gene family in Fragaria nilgerrensis reveals distinct roles of two FnFAD3 genes in peach-like aroma formation.Genes & genomics · 2026Article
- Molecular Characterization of Omega-3 Fatty Acid Desaturases Reveals Functional Conservation and Their Pivotal Role in Salt and Temperature Stress Adaptation inInternational journal of molecular sciences · 2026Article
- Natural Variation in TaFAD8-D Promoter Enhances Thermotolerance in Wheat Through Fatty Acid and Lipid Remodelling.Plant biotechnology journal · 2026Article
- Catalytic Tunnel Dynamics Explain Functional Divergence of FAD2 Homologs Underlying the Oleic-to-Linoleic Ratio inBiology · 2026Article
- Genome-wide characterization and expression pattern analysis ofPlant signaling & behavior · 2025Article
- Molecular Docking as a Key Driver of Biocontrol for Agri-Food Security.Biotech (Basel (Switzerland)) · 2025Review
- A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Phylogenetic Aspects of Higher Plant Lipid Fatty Acid Profile.International journal of molecular sciences · 2025Review
- Genome-Wide Identification and Drought Stress-Responsive Expression Profiling of the FAD Gene Family in Pear.Life (Basel, Switzerland) · 2025Article
- Telomere to telomere flax (Horticulture research · 2025Article
- Genetic diversity and adaptive evolutionary history of Sapindus in China: insights from whole-genome resequencing of 100 representative individuals.Plant biotechnology journal · 2025Article
- Divergent fatty acid desaturase 2 is essential for falcarindiol biosynthesis in carrot.Plant communications · 2025Article
- Whole-Genome Identification of the Flax Fatty Acid Desaturase Gene Family and Functional Analysis of the LuFAD2.1 Gene Under Cold Stress Conditions.Plant, cell & environment · 2025Article
- Unraveling the genetic basis of heat tolerance and yield in bread wheat: QTN discovery and Its KASP-assisted validation.BMC plant biology · 2025Article
- Unraveling Effects of miRNAs Associated with APR Leaf Rust Resistance Genes in Hybrid Forms of Common Wheat (International journal of molecular sciences · 2025Article
- Characterization of fatty acid desaturase gene family inFrontiers in plant science · 2025Article
- Genomic evolution and ecotype divergence in thraustochytrids: insights from comparative genomics and phylogenomics.Frontiers in microbiology · 2025Article
- Genome-wide analysis of fatty acid desaturase genes in moso bamboo (Phyllostachys edulis) reveal their important roles in abiotic stresses responses.BMC genomics · 2024Article
- Chia (Salvia hispanica L.), a functional 'superfood': new insights into its botanical, genetic and nutraceutical characteristics.Annals of botany · 2024Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundsFatty acid desaturases (FADs) introduce a double bond into the fatty acids acyl chain resulting in unsaturated fatty acids that have essential roles in plant development and response to biotic and abiotic stresses. Wheat germ oil, one of the important by-products of wheat, can be a good alternative for edible oils with clinical advantages due to the high amount of unsaturated fatty acids. Therefore, we performed a genome-wide analysis of the wheat FAD gene family (TaFADs).
results68 FAD genes were identified from the wheat genome. Based on the phylogenetic analysis, wheat FADs clustered into five subfamilies, including FAB2, FAD2/FAD6, FAD4, DES/SLD, and FAD3/FAD7/FAD8. The TaFADs were distributed on chromosomes 2A-7B with 0 to 10 introns. The Ka/Ks ratio was less than one for most of the duplicated pair genes revealed that the function of the genes had been maintained during the evolution. Several cis-acting elements related to hormones and stresses in the TaFADs promoters indicated the role of these genes in plant development and responses to environmental stresses. Likewise, 72 SSRs and 91 miRNAs in 36 and 47 TaFADs have been identified. According to RNA-seq data analysis, the highest expression in all developmental stages and tissues was related to TaFAB2.5, TaFAB2.12, TaFAB2.15, TaFAB2.17, TaFAB2.20, TaFAD2.1, TaFAD2.6, and TaFAD2.8 genes while the highest expression in response to temperature stress was related to TaFAD2.6, TaFAD2.8, TaFAB2.15, TaFAB2.17, and TaFAB2.20. Furthermore, docking simulations revealed several residues in the active site of TaFAD2.6 and TaFAD2.8 in close contact with the docked oleic acid that could be useful in future site-directed mutagenesis studies to increase the catalytic efficiency of them and subsequently improve agronomic quality and tolerance of wheat against environmental stresses.
conclusionsThis study provides comprehensive information that can lead to the detection of candidate genes for wheat genetic modification.
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