Evidence map›Paper›PMID 33167796›Full record

ReviewTherapeutic advances in respiratory disease

The use of nebulized pharmacotherapies during the COVID-19 pandemic.

Sanjay Sethi, Igor Z Barjaktarevic, Donald P Tashkin

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Estimated cost-savings from optimizing use of inhaled medications for inpatients with obstructive lung disease.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. SARS-CoV-2 in the Air Surrounding Patients during Nebulizer Therapy.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Article
  14. Review
  15. Review
  16. COVID Croup: Pediatric Croup Due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2; Covid-19).Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sanjay SethiUniversity at Buffalo, State University of New York, Clinical and Translational Research Center, 875 Ellicott St., Room 6045A, Buffalo, NY 14215, USA.
Igor Z BarjaktarevicDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Donald P TashkinDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), caused by the highly contagious novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a worldwide pandemic and currently represents a major public health issue. COVID-19 has highlighted the need for clear and accurate guidance on the use of aerosol-generating procedures, such as nebulization, for the treatment of patients with respiratory diseases with or without COVID-19. Despite the lack of evidence, there is heightened concern about the potential risk of transmission of SARS-CoV-2 in the form of aerosolized respiratory droplets during the nebulized treatment of patients with COVID-19. Consequently, the use of metered-dose inhalers (MDIs) has risen considerably as an alternative to nebulized therapy, which has led to inadequate supplies of MDIs in some parts of the United States. In this article, we review and discuss the role of nebulization in patients with SARS-CoV-2 and the treatment of noninfected patients with chronic respiratory diseases. The following two important questions are addressed: (1) should nebulized therapy be used in hospital or home settings by patients infected with SARS-CoV-2; and (2) should nebulized therapy be continued in patients already using it for chronic respiratory disease management in hospital or home settings?

Indexed as

BetacoronavirusNebulizers and VaporizersAdministration, InhalationAerosolsCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentHumansPandemicsPneumonia, ViralSARS-CoV-2Aerosolschronic respiratory diseaseCOVID-19handheld inhalernebulized therapySARS-CoV-2

Identifiers

PMID33167796
PMCPMC7675890
OpenAlexW3105768001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.