ArticleInternational journal of stroke : official journal of the International Stroke Society2021
Age and sex distribution of beat-to-beat blood pressure variability after transient ischemic attack and minor stroke: A population-based study.
Article in International journal of stroke : official journal of the International Stroke Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Blood pressure variability in acute stroke: Risk factors and association with functional outcomes at 1 month.European journal of neurology · 2024Article
- Changes in beat-to-beat blood pressure and pulse rate variability following stroke.Scientific reports · 2023Article
- Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Consistencies and Differences in Intermediate Physiological Phenotypes of Vascular Ageing between Ischaemic Stroke Aetiologies.Cerebrovascular diseases (Basel, Switzerland) · 2023Article
- Intra-beat biomarker for accurate continuous non-invasive blood pressure monitoring.Scientific reports · 2022Article
- Blood Pressure Variability and Cognitive Function: a Scoping Review.Current hypertension reports · 2022Article
- Article
- Blood Pressure Complexity Discriminates Pathological Beat-to-Beat Variability as a Marker of Vascular Aging.Journal of the American Heart Association · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundBeat-to-beat blood pressure variability is associated with increased stroke risk but its importance at different ages is unclear.
aimsTo determine the age-sex distribution of blood pressure variability in patients with transient ischemic stroke or minor stroke.
methodsIn consecutive patients within six weeks of transient ischemic stroke or non-disabling stroke (Oxford Vascular Study), non-invasive blood pressure was measured beat-to-beat over five minutes (Finometer). The age-sex distribution of blood pressure variability (residual coefficient of variation) was determined for systolic blood pressure and diastolic blood pressure. The risk of top-decile blood pressure variability was estimated (logistic regression), unadjusted, and adjusted for age, sex, and cardiovascular risk factors.
resultsIn 908 of 1013 patients, excluding 54 in atrial fibrillation and 51 with low quality recordings, residual coefficient of variation was positively skewed with a median systolic residual coefficient of variation of 4.2% (IQR 3.2-5.5) and diastolic residual coefficient of variation of 3.9% (3.0-5.5), with 90th centile thresholds of 7.2 and 7.3%. Median systolic residual coefficient of variation was higher in patients under 50 years (4.5 and 3.0-5.3) compared to 60-70 years (4.1 and 3.2-5.2), but rose to 4.5% (3.5-6.9) above 80 years, with an increasingly positive skew. The proportion of patients with markedly elevated blood pressure variability in the top-decile increased significantly per decade (OR 1.72, p < 0.001), after adjustment for sex and risk factors.
conclusionsMedian beat-to-beat blood pressure variability fell in midlife, reflecting loss of physiological, organized blood pressure variability. However, rates of markedly elevated blood pressure variability significantly increased with greater age, suggesting that blood pressure variability may be particularly important in older patients.
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