ArticleJournal of the American Chemical Society2020
Exploring the Molecular Conformation Space by Soft Molecule-Surface Collision.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Efficient Pretreatment of Burdock Straw with Ternary Deep Eutectic Solvents under Mild Conditions Improves Saccharification Efficiency.Applied biochemistry and biotechnology · 2026Article
- Automating Model Building for SPM Images of Biomolecules Using MISO.Journal of chemical information and modeling · 2026Article
- Topology Switching in Polymetallic Fragments Governed by Metal Encapsulation.Journal of the American Chemical Society · 2026Article
- Landing-Energy-Controlled Surface Conformation of Electrosprayed Foldamer Molecules on Au(111).ACS nano · 2026Article
- Self-Assembly, Rearrangement, and Disassembly of {CrAngewandte Chemie (International ed. in English) · 2025Article
- Rapid and Reliable Conformational Analysis of Glycans by Small Angle X-Ray Scattering Guided Molecular Dynamics Simulations.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Imaging Dihydrogen Bond-Driven Assembly of Borazine on Au(111).Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Scanning Probe Microscopy Characterization of Biomolecules enabled by Mass-Selective, Soft-landing Electrospray Ion Beam Deposition.Chemphyschem : a European journal of chemical physics and physical chemistry · 2024Article
- Atomically resolved imaging of the conformations and adsorption geometries of individual β-cyclodextrins with non-contact AFM.Nature communications · 2024Article
- Spontaneous ligand loss by soft landed [Ni(bpy)Chemical science · 2024Article
- Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator.The journal of physical chemistry letters · 2024Article
- Controlled Formation of Nanoribbons and Their Heterostructures via Assembly of Mass-Selected Inorganic Ions.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Visualizing the structural diversity of glycoconjugates.Nature chemical biology · 2024Article
- Molecular sensitised probe for amino acid recognition within peptide sequences.Nature communications · 2023Article
- Direct observation of glycans bonded to proteins and lipids at the single-molecule level.Science (New York, N.Y.) · 2023Article
- Controlled Surface Modification to Revive Shallow NVNano letters · 2023Article
- Electrospray ion beam deposition plus low-energy electron holography as a tool for imaging individual biomolecules.Essays in biochemistry · 2023Article
- Soft landing of polyatomic anions onto three-dimensional semiconductive and conductive substrates.Nanoscale advances · 2023Article
- Landing Proteins on Graphene Trampoline Preserves Their Gas-Phase Folding on the Surface.ACS central science · 2023Article
- Synthetic Approaches to Break the Chemical Shift Degeneracy of Glycans.Chembiochem : a European journal of chemical biology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecules function by adopting multiple conformations. Such dynamics are governed by the conformation landscape whose study requires characterization of the ground and excited conformation states. Here, the conformational landscape of a molecule is sampled by exciting an initial gas-phase molecular conformer into diverse conformation states, using soft molecule-surface collision (0.5-5.0 eV). The resulting ground and excited molecular conformations, adsorbed on the surface, are imaged at the single-molecule level. This technique permits the exploration of oligosaccharide conformations, until now, limited by the high flexibility of oligosaccharides and ensemble-averaged analytical methods. As a model for cellulose, cellohexaose chains are observed in two conformational extremes, the typical "extended" chain and the atypical "coiled" chain-the latter identified as the gas-phase conformer preserved on the surface. Observing conformations between these two extremes reveals the physical properties of cellohexaose, behaving as a rigid ribbon that becomes flexible when twisted. The conformation space of any molecule that can be electrosprayed can now be explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.