Evidence map›Paper›PMID 33167538›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Molecular Dynamics Studies of Poly(Lactic Acid) Nanoparticles and Their Interactions with Vitamin E and TLR Agonists Pam

Simon Megy, Stephanie Aguero, David Da Costa, Myriam Lamrayah, Morgane Berthet, Charlotte Primard, Bernard Verrier, Raphael Terreux

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Simon MegyPRABI (Pôle Rhône-Alpes de Bioinformatique), Lyon Gerland, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.
Stephanie AgueroPRABI (Pôle Rhône-Alpes de Bioinformatique), Lyon Gerland, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.
David Da CostaColloidal Vectors and Tissue Transport, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.ORCID 0000-0002-9080-0292
Myriam LamrayahColloidal Vectors and Tissue Transport, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.ORCID 0000-0002-8880-3048
Morgane BerthetColloidal Vectors and Tissue Transport, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.
Charlotte PrimardAdjuvatis, 7 Passage du Vercors, 69007 Lyon, France.ORCID 0000-0002-3341-9161
Bernard VerrierColloidal Vectors and Tissue Transport, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.
Raphael TerreuxPRABI (Pôle Rhône-Alpes de Bioinformatique), Lyon Gerland, UMR5305, LBTI, IBCP, Lyon 1 University, 7 Passage du Vercors, 69367 Lyon CEDEX 07, France.ORCID 0000-0003-1243-7413
Université Claude Bernard Lyon 1 · FR

Funding

Agence Nationale de la Recherche ANR-20-COVI-000 / CovidNanoMed
6 · The paper itself

Abstract

Poly(lactic acid) (PLA) nanoparticles (NPs) are widely investigated due to their bioresorbable, biocompatible and low immunogen properties. Interestingly, many recent studies show that they can be efficiently used as drug delivery systems or as adjuvants to enhance vaccine efficacy. Our work focuses on the molecular mechanisms involved during the nanoprecipitation of PLA NPs from concentrated solutions of lactic acid polymeric chains, and their specific interactions with biologically relevant molecules. In this study, we evaluated the ability of a PLA-based nanoparticle drug carrier to vectorize either vitamin E or the Toll-like receptor (TLR) agonists Pam

Indexed as

dissipative particle dynamicsmolecular dynamicsnanoparticlesPam1CSK4Pam3CSK4polylactic acidToll-like receptorvitamin E

Identifiers

PMID33167538
PMCPMC7694526
OpenAlexW3097739209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.