Evidence map›Paper›PMID 33167393›Full record

ReviewCancers2020

Electronic Cigarettes and Head and Neck Cancer Risk-Current State of Art.

Marta Szukalska, Krzysztof Szyfter, Ewa Florek, Juan P Rodrigo, Alessandra Rinaldo, Antti A Mäkitie, Primož Strojan, Robert P Takes, Carlos Suárez, Nabil F Saba and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  12. Alarming triad of progressive hoarseness in a male smoker.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 8 countries.

Marta SzukalskaLaboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.ORCID 0000-0002-3295-2546
Krzysztof SzyfterInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Ewa FlorekLaboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.ORCID 0000-0002-2689-3009
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias-University of Oviedo, 33011 Oviedo, Spain.ORCID 0000-0003-3063-0890
Alessandra RinaldoUniversity of Udine School of Medicine, 33100 Udine, Italy.ORCID 0000-0001-7956-6709
Antti A MäkitieDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS Helsinki, Finland.ORCID 0000-0002-0451-2404
Primož StrojanDepartment of Radiation Oncology, Institute of Oncology, 1000 Ljubljana, Slovenia.ORCID 0000-0002-0445-112X
Robert P TakesDepartment of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Carlos SuárezInstituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, CIBERONC, 33011 Oviedo, Spain.
Nabil F SabaDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-4972-1477
Boudewijn J M BraakhuisMember of the International Head and Neck Scientific Group, 35100 Padua, Italy.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, 35100 Padua, Italy.
Poznan University of Medical Sciences · PLUniversidad de Oviedo · ESEmory University · USInstitute of Human Genetics · PLInstitute of Oncology Ljubljana · SIRadboud University Nijmegen · NLUniversity of Helsinki · FIUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

E-cigarettes have become increasingly popular in the last decade and are considered less harmful than traditional tobacco products due to the lower content of toxic and carcinogenic compounds. However, this is still a controversial issue. This paper contains a review of previous reports on the composition of e-cigarettes and their impact on the pathogenesis and risk of head and neck cancer (HNC). The objective of the review was to compare the molecular and health effects of e-cigarette use in relation to the effects of traditional cigarette smoking in the upper respiratory tract, and to assess the safety and effect of e-cigarettes on HNC risk. A review for English language articles published until 31 August 2020 was made, using a PubMed (including MEDLINE), CINAHL Plus, Embase, Cochrane Library and Web of Science data. The authors reviewed articles on both toxic and carcinogenic compounds contained in e-cigarettes and their molecular and health effects on the upper respiratory tract in comparison to tobacco cigarettes. The risk of developing head and neck squamous cell carcinoma (HNSCC) remains lower in users of e-cigarettes compared with tobacco smokers. However, more long-term studies are needed to better address the safety of e-cigarettes.

Indexed as

carcinogenic compoundselectronic cigaretteshead and neck cancerhead and neck squamous cell carcinomatoxicity

Identifiers

PMID33167393
PMCPMC7694366
OpenAlexW3096696802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.