Evidence map›Paper›PMID 33167378›Full record

ReviewInternational journal of molecular sciences2020

Extracellular Vesicles and the Oviduct Function.

Emily A Harris, Kalli K Stephens, Wipawee Winuthayanon

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
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  11. Article
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  13. Article
  14. Establishment and Maintenance of Feline Pregnancy-A Comprehensive Review.Animals : an open access journal from MDPI · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Extracellular vesicles: key mediators inFrontiers in veterinary science · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily A HarrisCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Kalli K StephensCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-9323-3764
Wipawee WinuthayanonCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-5196-8471
Washington State University · US

Funding

The actions of steroid hormones on oviduct functionR01HD097087 · NICHD · WASHINGTON STATE UNIVERSITY · PI WINUTHAYANON, WIPAWEE · 2019 to 2023
$1.7M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD097087Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD097087-02S1Louis Stokes Alliance for Minority Participation Research Award (LSAMP)NICHD NIH HHS R01 HD097087
6 · The paper itself

Abstract

In mammals, the oviduct (or the Fallopian tube in humans) can be divided into the infundibulum (responsible for oocyte pick-up), ampulla (site of fertilization), isthmus (where preimplantation embryos develop), and uterotubal junction (where embryos transit to the uterus). The oviductal fluid, as well as extracellular vesicles produced from the oviduct epithelial cells, referred to as oEVs, have been shown to improve the fertilization process, prevent polyspermy, and aid in embryo development. oEVs contain molecular cargos (such as miRNAs, mRNAs, proteins, and lipids) that can be delivered and fuse to recipient cells. oEVs produced from the ampulla appear to be functionally distinct from those produced from the isthmus. In multiple species including mice, cats, dogs, pigs, and cows, oEVs can be incorporated into the oocytes, sperm, and embryos. In this review, we show the positive impact of oEVs on gamete function as well as blastocyst development and how they may improve embryo quality in in vitro conditions in an assisted reproductive technology setting for rodents, domestic animals, farm animals, and humans.

Indexed as

AnimalsBlastocystCatsCattleCells, CulturedDogsEmbryonic DevelopmentExtracellular VesiclesFallopian TubesFemaleGerm CellsHumansMiceOviductsPregnancyReproductive Techniques, Assistedeggembryoexosomeextracellular vesiclefallopian tubemicrovesicleoocyteoviductoviductosomesperm

Identifiers

PMID33167378
PMCPMC7663821
OpenAlexW3095749671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.