Evidence map›Paper›PMID 33167342›Full record

ArticleCells2020

Pro-Inflammatory Role of AQP4 in Mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP.

Agnete Prydz, Katja Stahl, Soulmaz Zahl, Nadia Skauli, Øivind Skare, Ole Petter Ottersen, Mahmood Amiry-Moghaddam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Aquaporin-4 and Parkinson's Disease.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Glial Reaction in a Neuroinflammatory Model of Parkinson's Disease.Bulletin of experimental biology and medicine · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Agnete PrydzLaboratory of Molecular Neuroscience, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317 Oslo, Norway.
Katja StahlLaboratory of Molecular Neuroscience, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317 Oslo, Norway.
Soulmaz ZahlLaboratory of Molecular Neuroscience, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317 Oslo, Norway.
Nadia SkauliLaboratory of Molecular Neuroscience, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317 Oslo, Norway.
Øivind SkareDepartment of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Gydas vei 8, 0363 Oslo, Norway.ORCID 0000-0001-8043-2820
Ole Petter OttersenPresident's Office, Karolinska Institutet, Nobels väg 6, 171 77 Stockholm, Sweden.
Mahmood Amiry-MoghaddamLaboratory of Molecular Neuroscience, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317 Oslo, Norway.ORCID 0000-0003-1071-1247
University of Oslo · NOKarolinska Institutet · SENational Institute of Occupational Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquaporin-4 (AQP4) is critically involved in brain water and volume homeostasis and has been implicated in a wide range of pathological conditions. Notably, evidence has been accrued to suggest that AQP4 plays a proinflammatory role by promoting release of astrocytic cytokines that activate microglia and other astrocytes. Neuroinflammation is a hallmark of Parkinson's disease (PD), and we have previously shown that astrocytes in substantia nigra (SN) are enriched in AQP4 relative to cortical astrocytes, and that their complement of AQP4 is further increased following treatment with the parkinsonogenic toxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Here, we investigated the effect of

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsAquaporin 4AstrocytesDopaminergic NeuronsFemaleGene Expression RegulationGlial Fibrillary Acidic ProteinInflammationInjectionsMaleMesencephalonMice, Inbred C57BLNeurogliaParkinson DiseaseRNA, Messenger1-Methyl-4-phenylpyridiniumAquaporin 4Glial Fibrillary Acidic ProteinRNA, MessengerAQP4astrocytemicrogliaMPP+neuroinflammationParkinson’s disease

Identifiers

PMID33167342
PMCPMC7694382
OpenAlexW3096498935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.