ArticleGenes2020
Application of CRISPR/Cas9 Nuclease in Amphioxus Genome Editing.
Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Evolutionary dynamics of sex determination in Branchiostoma belcheri driven by repeated transposition of a single novel gene.Nature communications · 2026Article
- Amphioxus (Branchiostoma lanceolatum) in the North Adriatic Sea: ecological observations and spawning behavior.Integrative zoology · 2025Article
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories.Nature ecology & evolution · 2024Article
- Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus.eLife · 2024Article
- Ancestral role of Pax6 in chordate brain regionalization.Frontiers in cell and developmental biology · 2024Article
- Article
- Recent Advances in CRISPR/Cas-Based Biosensors for Protein Detection.Bioengineering (Basel, Switzerland) · 2022Review
- Highly distinct genetic programs for peripheral nervous system formation in chordates.BMC biology · 2022Article
- The Evolution of Invertebrate Animals.Genes · 2022Article
- An Updated Staging System for Cephalochordate Development: One Table Suits Them All.Frontiers in cell and developmental biology · 2021Article
- A Potential Method for Rapid Screening of Amphioxus Founder Harboring Germline Mutation and Transgene.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cephalochordate amphioxus is a promising animal model for studying the origin of vertebrates due to its key phylogenetic position among chordates. Although transcription activator-like effector nucleases (TALENs) have been adopted in amphioxus genome editing, its labor-intensive construction of TALEN proteins limits its usage in many laboratories. Here we reported an application of the CRISPR/Cas9 system, a more amenable genome editing method, in this group of animals. Our data showed that while co-injection of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.