ArticlePloS one2020
A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Methodological Considerations on COVID-19 Mortality in Cancer Patients: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity.BMC public health · 2021Pooled it
- Clinical Significance of Plasma D-Dimer in COVID-19 Mortality.Frontiers in medicine · 2021Pooled it
- Biomarkers of Multiorgan Failure in COVID-19: A Predictive Framework for Disease Severity and Clinical Outcomes.Saudi medical journal · 2026Article
- Admission Hyperglycemia as an Early Predictor of Severity and Poor Prognosis in COVID-19: A Retrospective Cohort Study of Hospitalized Adults.Journal of clinical medicine · 2025Article
- Article
- Association between D-dimers and in-hospital all-cause mortality in COVID-19 patients at a tertiary hospital in South Africa: A retrospective study.African journal of thoracic and critical care medicine · 2025Article
- Clinical and Laboratory Predictors of Mortality in Severe COVID-19 Pneumonia: A Retrospective Study from India.Thoracic research and practice · 2023Article
- Clinical Risk Factors of Need for Intensive Care Unit Admission of COVID-19 Patients; a Cross-sectional Study.Archives of academic emergency medicine · 2023Article
- D-Dimer as a Sensitive Biomarker of Survival Rate in Patients with COVID-19.The Eurasian journal of medicine · 2022Article
- Hemostatic system and COVID-19 crosstalk: A review of the available evidence.World journal of methodology · 2022Review
- Discrepancy between biomarkers of lung injury and 1-year mortality in COVID-19.European journal of clinical investigation · 2022Observational
- Clinical Characteristics and Risk Factors Associated with Severe Disease Progression among COVID-19 Patients In Wad Medani Isolation Centers: A Multicenter Retrospective Cross-Sectional Study.Health science reports · 2022Article
- Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.PloS one · 2022Article
- Time-to-event assessment for the discovery of the proper prognostic value of clinical biomarkers optimized for COVID-19.Clinics (Sao Paulo, Brazil) · 2022Article
- Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic.Journal of clinical medicine · 2021Article
- Predictors of intubation and mortality in COVID-19 patients: a retrospective study.Journal of anesthesia, analgesia and critical care · 2021Article
- Course of COVID-19 Based on Admission D-Dimer Levels and Its Influence on Thrombosis and Mortality.Journal of clinical medicine research · 2021Article
- Correlation of Coagulation Parameters With Clinical Outcomes During the Coronavirus-19 Surge in New York: Observational Cohort.Frontiers in physiology · 2021Article
- Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19.International journal of biological sciences · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients.
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