ArticleNeurobiology of aging2021
Metabolic syndrome and its components in relation to in vivo brain amyloid and neurodegeneration in late middle age.
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In one paragraph
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Metabolic syndrome is associated with accelerated brain aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Genetic and vascular risk factors for ischemic stroke and cortical morphometry in individuals without a history of stroke: A UK Biobank observational cohort study.NeuroImage. Clinical · 2024Observational
- Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study.Translational psychiatry · 2023Article
- Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease.The Journal of clinical investigation · 2022Article
- Hallmarks of neurodegenerative disease: A systems pharmacology perspective.CPT: pharmacometrics & systems pharmacology · 2022Review
- Alzheimer's Disease and Inflammaging.Brain sciences · 2022Review
- Metabolic Factors Are Related to Brain Amyloid Among Mexican Americans: A HABS-HD Study.Journal of Alzheimer's disease : JAD · 2022Article
- Metabolic Syndrome and Cognitive Function.Current cardiology reports · 2021Review
- Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults.Neurobiology of aging · 2021Article
- From Metabolic Syndrome to Neurological Diseases: Role of Autophagy.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Priya PaltaDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: pp2464@cumc.columbia.edu.
Brady RipponDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Mouna TahmiDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Greysi SherwoodDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Luisa SotoDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Fernando CeballosDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Krystal LaingDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Hengda HeDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Christiane ReitzDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
Qolamreza RazlighiDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Jeanne A TeresiResearch Division, Hebrew Home in Riverdale, Bronx, NY, USA; Columbia University Stroud Center at New York State Psychiatric Center, New York, NY, USA.
Herman MorenoDepartment of Neurology and Pharmacology/Physiology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Adam M BrickmanDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
José A LuchsingerDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University · USColumbia University Irving Medical Center · USCornell University · USHebrew Home · USSUNY Downstate Health Sciences University · US
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MMetformin in Alzheimer's dementia Prevention (MAP)R01AG062624 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HANLEY, DANIEL F, LUCHSINGER, JOSE ALEJANDRO · 2019 to 2025
$37.8MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1MResiding in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ORNA INTRATOR · 2010 to 2026
$21.9MDiabetes Status and Brain Amyloid in Middle Aged HispanicsR01AG050440 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUCHSINGER, JOSE ALEJANDRO · 2015 to 2025
$21.9MPilot CoreP30AG022845 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Manney Carrington Reid, ELAINE WETHINGTON · 2003 to 2026
$15.2MInterdisciplinary Research to Understand the Interplay of Diabetes, Cerebrovascular disease and Alzheimers diseaseRF1AG051556 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, LUCHSINGER, JOSE ALEJANDRO · 2015 to 2019
$9.7MResearch Education CoreP30AG059303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN, Jennifer Jaie Manly · 2018 to 2026
$6.0MMidcareer Award for Research in Dementia Risk Factors and PreventionK24AG045334 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jose Alejandro Luchsinger · 2016 to 2026
$1.5MPhysical Activity and Preservation of Cognitive FunctionR00AG052830 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PALTA, PRIYA · 2019 to 2021
$1.1MPhysical Activity and Preservation of Cognitive FunctionK99AG052830 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PALTA, PRIYA · 2016 to 2017
$151kNCATS NIH HHS UL1 TR001873NIA NIH HHS K24 AG045334NIA NIH HHS K99 AG052830NIA NIH HHS P30 AG022845NIA NIH HHS P30 AG028741NIA NIH HHS P30 AG059303NIA NIH HHS P30 AG066462NIA NIH HHS R00 AG052830NIA NIH HHS R01 AG050440NIA NIH HHS R01 AG062624NIA NIH HHS RF1 AG051556
Abstract
Metabolic syndrome (MetS) is associated with dementia, but it is unclear whether MetS is related to Alzheimer's disease (AD). We investigated the association of MetS with brain amyloid, a key AD feature, and neurodegeneration. A community-based sample of 350 middle-aged Hispanics in New York City had cerebral amyloid β (Aβ) burden ascertained with
Indexed as
Nerve DegenerationAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsBlood GlucoseBrainDiffusion Tensor ImagingFemaleHispanic or LatinoHumansMaleMetabolic SyndromeMiddle AgedNew YorkRisk4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbeneAmyloid beta-PeptidesAniline CompoundsBlood GlucoseStilbenesTriglyceridesAlzheimer's diseaseEpidemiologyMetabolic syndromeNeuroimaging
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.