Evidence map›Paper›PMID 33166868›Full record

ArticleRedox biology2021

Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants.

Samuel J Gentle, Khandaker A Ahmed, Nengjun Yi, Casey D Morrow, Namasivayam Ambalavanan, Charitharth V Lal, Rakesh P Patel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Samuel J GentleDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: sjgentle@uabmc.edu.
Khandaker A AhmedDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nengjun YiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Casey D MorrowDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Charitharth V LalDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Rakesh P PatelDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USUniversity of Alabama at Birmingham Hospital · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
Oral nitrate metabolism as a predictor for bronchopulmonary in preterm infantsR21HD100917 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GENTLE, SAMUEL J, PATEL, RAKESH P. · 2020 to 2021
$408k
NICHD NIH HHS R21 HD100917NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

Oral microbiome mediated nitrate reductase (NR) activity regulates nitric oxide (NO) bioavailability and signaling. While deficits in NO-bioavailability impact several morbidities of extreme prematurity including bronchopulmonary dysplasia (BPD), whether oral NR activity is associated with morbidities of prematurity is not known. We characterized NR activity in extremely preterm infants from birth until 34 weeks' post menstrual age (PMA), determined whether changes in the oral microbiome contribute to changes in NR activity, and determined whether changes in NR activity correlated with disease. In this single center prospective cohort study (n = 28), we observed two surprising findings: (1) NR activity unexpectedly peaked at 29 weeks' PMA (p < 0.05) and (2) when infants were stratified for BPD status, infants who developed BPD had significantly less NR activity at 29 weeks' PMA compared to infants who did not develop BPD. Oral microbiota and NR activity may play a role in BPD development in extremely preterm infants, indicating potential for disease prediction and therapeutic targeting.

Indexed as

Bronchopulmonary DysplasiaMicrobiotaNitrate ReductasesHumansInfantInfant, Extremely PrematureInfant, NewbornMouthNitric OxideProspective StudiesNitrate ReductasesNitric OxideBronchopulmonary dysplasiaExtreme prematurityNitrate reductaseNitric oxideNitrite

Identifiers

PMID33166868
PMCPMC7658701
OpenAlexW3095598209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.