ArticleToxicology and applied pharmacology2020
Biological effects of inhaled hydraulic fracturing sand dust. IX. Summary and significance.
Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Biological effects of inhaled hydraulic fracturing sand dust. II. Particle characterization and pulmonary effects 30 d following intratracheal instillation.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust. IV. Pulmonary effects.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust VII. Neuroinflammation and altered synaptic protein expression.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust. I. Scope of the investigation.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust. V. Pulmonary inflammatory, cytotoxic and oxidant effects.Toxicology and applied pharmacology · 2020Article
- Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects.Toxicology and applied pharmacology · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
An investigation into the potential toxicological effects of fracking sand dust (FSD), collected from unconventional gas drilling sites, has been undertaken, along with characterization of their chemical and biophysical properties. Using intratracheal instillation of nine FSDs in rats and a whole body 4-d inhalation model for one of the FSDs, i.e., FSD 8, and related in vivo and in vitro experiments, the effects of nine FSDs on the respiratory, cardiovascular and immune systems, brain and kidney were reported in the preceding eight tandem papers. Here, a summary is given of the key observations made in the organ systems reported in the individual studies. The major finding that inhaled FSD 8 elicits responses in extra-pulmonary organ systems is unexpected, as is the observation that the pulmonary effects of inhaled FSD 8 are attenuated relative to forms of crystalline silica more frequently used in animal studies, i.e., MIN-U-SIL® 5. An attempt is made to understand the basis for the extra-pulmonary toxicity and comparatively attenuated pulmonary toxicity of FSD 8.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.