Evidence map›Paper›PMID 33166473›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to

Benjamin G Wu, Imran Sulaiman, Jun-Chieh J Tsay, Luisanny Perez, Brendan Franca, Yonghua Li, Jing Wang, Amber N Gonzalez, Mariam El-Ashmawy, Joseph Carpenito and 17 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 128 citations in OpenAlex.

  1. Trial
  2. Myeloid cell reprogramming drives enhanced defense againstProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Journal of bacteriology · 2026
    Review
  5. Inter-Organ Communication in Pulmonary Fibrosis: Systemic Modifiers of a Lung-Centered Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  6. Review
  7. Article
  8. Article
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  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 2 countries.

Benjamin G WuDivision of Pulmonary, Critical Care and Sleep Medicine.ORCID 0000-0001-8547-5678
Imran SulaimanDivision of Pulmonary, Critical Care and Sleep Medicine.
Jun-Chieh J TsayDivision of Pulmonary, Critical Care and Sleep Medicine.
Luisanny PerezDivision of Pulmonary, Critical Care and Sleep Medicine.
Brendan FrancaDivision of Pulmonary, Critical Care and Sleep Medicine.
Yonghua LiDivision of Pulmonary, Critical Care and Sleep Medicine.
Jing WangDivision of Pulmonary, Critical Care and Sleep Medicine.
Amber N GonzalezDivision of Pulmonary, Critical Care and Sleep Medicine.
Mariam El-AshmawyDepartment of Medicine.
Joseph CarpenitoDivision of Pulmonary, Critical Care and Sleep Medicine.
Evan OlsenDivision of Pulmonary, Critical Care and Sleep Medicine.
Maya SauthoffDivision of Pulmonary, Critical Care and Sleep Medicine.
Kevin YieDivision of Pulmonary, Critical Care and Sleep Medicine.
Xiuxiu LiuDivision of Pediatrics, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai, China.
Nan ShenDepartment of Genetics and Genomic Sciences and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Jose C ClementeDepartment of Genetics and Genomic Sciences and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Bianca KapoorDepartment of Medicine.
Tonia ZangariDepartment of Microbiology.
Valeria MezzanoDivision of Cardiology, Department of Medicine and.
Cynthia LoomisDivision of Cardiology, Department of Medicine and.
Michael D WeidenDivision of Pulmonary, Critical Care and Sleep Medicine.
Sergei B KoralovDepartment of Pathology, NYU Langone Health, New York, New York.
Jeanine D'ArmientoDepartment of Anesthesiology, School of Medicine, Columbia University, New York, New York; and.
Sunil K AhujaUniversity of Texas Health Science Center, San Antonio, Texas.
Xue-Ru WuDepartment of Pathology, NYU Langone Health, New York, New York.
Jeffrey N WeiserDepartment of Microbiology.
Leopoldo N SegalDivision of Pulmonary, Critical Care and Sleep Medicine.
SleepMed · USEmory University Hospital · USIcahn School of Medicine at Mount Sinai · USNYU Langone Health · USVA NY Harbor Healthcare System · USCapital Medical University · CNCity University of New York · USShanghai University of Traditional Chinese Medicine · CNThe University of Texas Health Science Center at San Antonio · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Reagent/Service CoreP01CA165980 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WU, XUE-RU · 2013 to 2023
$13.5M
Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancerR37CA244775 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Leopoldo Nicolas Segal · 2020 to 2026
$4.7M
Mechanisms of Pneumococcal Persistence During CarriageR37AI038446 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeffrey Neal Weiser · 2020 to 2026
$3.8M
Targeting Pneumococcal TransmissionR01AI150893 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 2020 to 2024
$3.3M
Microbial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1R01HL125816 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2015 to 2019
$3.3M
Research Training for Physician-Scientists in Gastrointestinal OncologyT32CA193111 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WOLFGANG, CHRISTOPHER L. · 2015 to 2024
$2.7M
Lung Microbiome and Inflammation in Early COPDK23AI102970 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGAL, LEOPOLDO NICOLAS · 2014 to 2017
$754k
Role of Lung and Gut Microbiome in Lung Inflammation and EmphysemaR21ES029389 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M · 2019 to 2020
$446k
Multispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359k
Molecular and Genetic Studies of Bladder TumorigenesisI01BX002049 · VA · VA NEW YORK HARBOR HLTHCARE/SYS/BROOKLYN · PI WU, XUE-RU · 2014 to 2022
–
BLRD VA I01 BX002049BLRD VA IK6 BX004479NCATS NIH HHS UL1 TR001445NCI NIH HHS P01 CA165980NCI NIH HHS P30 CA016087NCI NIH HHS R37 CA244775NCI NIH HHS T32 CA193111NHLBI NIH HHS R01 HL125816NIAID NIH HHS K23 AI102970NIAID NIH HHS L30 AI138249NIAID NIH HHS R01 AI150893NIAID NIH HHS R37 AI038446NIEHS NIH HHS R21 ES029389NIH HHS S10 OD021747
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Streptococcus pneumoniaeAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLMyeloid Differentiation Factor 88Pneumococcal InfectionsPrevotella melaninogenicaStreptococcus mitisTh17 CellsVeillonellaMyd88 protein, mouseMyeloid Differentiation Factor 88inflammationmicrobiomepathogen susceptibilitytranscriptomics

Identifiers

PMID33166473
PMCPMC8314894
OpenAlexW3098880949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.