ArticleNucleic acids research2020
The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs.Cellular & molecular biology letters · 2026Article
- A genome-wide association study reveals additive and recessive alleles affecting male fertility in pigs.Journal of animal science and biotechnology · 2025Article
- New feature of hMEIOB and hSPATA22 binding to ssDNA from a single-molecule perspective.Acta biochimica et biophysica Sinica · 2025Article
- The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.Nucleic acids research · 2025Article
- Spatiotemporal dynamics of early oogenesis in pigs.Genome biology · 2025Article
- TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.eLife · 2024Article
- Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum.PLoS pathogens · 2024Article
- In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis.Nature communications · 2023Article
- CDKN2AIP is critical for spermiogenesis and germ cell development.Cell & bioscience · 2022Article
- SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.Nucleic acids research · 2022Article
- RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes.Science advances · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the human infertility-associated missense mutation (N64I) in MEIOB causes protein degradation and reduced crossover formation in mouse testes. Although the MEIOB N64I substitution is associated with human infertility, the point mutant mice are fertile despite meiotic defects. Meiob mutagenesis identifies serine 67 as a critical residue for MEIOB. Biochemically, these two mutations (N64I and S67 deletion) cause self-aggregation of MEIOB and sharply reduced protein half-life. Molecular genetic analyses of both point mutants reveal an important role for MEIOB in crossover formation in late meiotic recombination. Furthermore, we find that the MEIOB protein levels directly correlate with the severity of meiotic defects. Our results demonstrate that MEIOB regulates meiotic recombination in a dosage-dependent manner.
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