Evidence map›Paper›PMID 33166379›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2021

Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.

Alexander V Alekseyenko, Bashir Hamidi, Trevor D Faith, Keith A Crandall, Jennifer G Powers, Christopher L Metts, James E Madory, Steven L Carroll, Jihad S Obeid, Leslie A Lenert

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Not all phenotypes are created equal: covariates of success in e-phenotype specification.Journal of the American Medical Informatics Association : JAMIA · 2023
    Article
  3. The maturation of clinical research informatics as a subdomain of biomedical informatics.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander V AlekseyenkoBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Bashir HamidiBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Trevor D FaithBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Keith A CrandallDepartment of Biostatistics & Bioinformatics, Computational Biology Institute, Milken Institute School of Public Health, George Washington University, Washington DC, USA.
Jennifer G PowersDepartment of Dermatology, University of Iowa, Iowa City, Iowa, USA.
Christopher L MettsBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
James E MadoryDivision of Pathology Informatics, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Steven L CarrollDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Jihad S ObeidBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Leslie A LenertBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TURNER, DAVID PAUL · 2017 to 2023
$6.7M
Biospecimen procurement and tissue microarray manufacture for the CHTNUM1CA239752 · NCI · UNIVERSITY OF VIRGINIA · PI Christopher A. Moskaluk · 2019 to 2026
$6.6M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI WARSHAMANA-GREENE, GNANA SAKUNTALA · 2017 to 2023
$6.1M
Using connectomics to characterize risk for Alzheimer's DiseaseR01AG055132 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JOSEPH, JANE E, MINTZER, JACOBO · 2017 to 2021
$3.7M
Distance-based Panomic Analytics for Microbiome DataR01LM012517 · NLM · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ALEKSEYENKO, ALEXANDER V · 2018 to 2021
$1.3M
Increasing Access to Clinical Microbiome Specimens via a Living µbiome BankR21TR002513 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ALEKSEYENKO, ALEXANDER V · 2018 to 2019
$439k
NCATS NIH HHS R21 TR002513NCATS NIH HHS UL1 TR001450NCI NIH HHS P30 CA138313NCI NIH HHS U54 CA210962NCI NIH HHS U54 CA210963NCI NIH HHS UM1 CA239752NIA NIH HHS R01 AG055132NLM NIH HHS R01 LM012517
6 · The paper itself

Abstract

The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens. The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. We further present an extension to our solution, the Living µBiome Bank, that allows the user to request and receive phenotyped specimen microbiome data. We discuss the details of the implementation of the LBB system and the necessary regulatory oversight for this solution. The conducted institutional focus group of translational investigators indicates an overall positive sentiment towards potential scientific results generated with the use of LBB. Reference implementation of LBB is available at https://LivingBioBank.musc.edu.

Indexed as

Databases, FactualPhenotypeTranslational Research, BiomedicalBiological Specimen BanksData WarehousingHumansMicrobiotaSurveys and Questionnairesjust-in-time biobankingphenotyped specimen dataphenotyped specimenstranslational research services

Identifiers

PMID33166379
PMCPMC7810447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.