Evidence map›Paper›PMID 33166335›Full record

ArticlePloS one2020

Disorder-specific brain volumetric abnormalities in Attention-Deficit/Hyperactivity Disorder relative to Autism Spectrum Disorder.

Ariadna Albajara Sáenz, Peter Van Schuerbeek, Simon Baijot, Mathilde Septier, Nicolas Deconinck, Pierre Defresne, Véronique Delvenne, Gianfranco Passeri, Hubert Raeymaekers, Hichem Slama and 5 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Article
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  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Ariadna Albajara SáenzNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0002-8259-0678
Peter Van SchuerbeekDepartment of Radiology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
Simon BaijotNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Mathilde SeptierHôpital Universitaire Robert Debré, Paris, France.
Nicolas DeconinckHôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium.
Pierre DefresneFondation SUSA-Université de Mons, Mons, Belgium.
Véronique DelvenneHôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium.
Gianfranco PasseriHôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium.
Hubert RaeymaekersDepartment of Radiology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.ORCID 0000-0003-0041-6359
Hichem SlamaNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Laurent VictoorPsyPluriel, Centre Européen de Psychologie Médicale, Brussels, Belgium.
Eric WillayeFondation SUSA-Université de Mons, Mons, Belgium.
Philippe PeigneuxNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Thomas VillemonteixNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Isabelle MassatNeuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences (CRCN), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Université Libre de Bruxelles · BEQueen Fabiola Children's University Hospital · BEUniversitair Ziekenhuis Brussel · BEUniversity of Mons · BEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overlap/distinctiveness between Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) has been increasingly investigated in recent years, particularly since the DSM-5 allows the dual diagnosis of ASD and ADHD, but the underlying brain mechanisms remain unclear. Although both disorders are associated with brain volumetric abnormalities, it is necessary to unfold the shared and specific volume abnormalities that could contribute to explain the similarities and differences in the clinical and neurocognitive profiles between ADHD and ASD. In this voxel-based morphometry (VBM) study, regional grey matter volumes (GMV) were compared between 22 children with ADHD, 18 children with ASD and 17 typically developing (TD) children aged 8 to 12 years old, controlling for age and total intracranial volume. When compared to TD children or children with ASD, children with ADHD had a larger left precuneus, and a smaller right thalamus, suggesting that these brain abnormalities are specific to ADHD relative to ASD. Overall, this study contributes to the delineation of disorder-specific structural abnormalities in ADHD and ASD.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderBrainCase-Control StudiesChildFemaleGray MatterHumansMagnetic Resonance ImagingMaleThalamus

Identifiers

PMID33166335
PMCPMC7652272
OpenAlexW3102156264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.