ArticlePLoS computational biology2020
Neural mass modeling of slow-fast dynamics of seizure initiation and abortion.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Emergence of multifrequency activity in a laminar neural mass model.PLoS computational biology · 2026Article
- Analyzing the normal and epileptic output of a neural mass model based on cyclic-small gain theorem.Scientific reports · 2025Article
- Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes.Neurochemical research · 2025Article
- Expansion of epileptogenic networks via neuroplasticity in neural mass models.PLoS computational biology · 2024Article
- Dynamic prediction of nonlinear waveform transitions in a thalamo-cortical neural network under a square sensory control.Cognitive neurodynamics · 2024Article
- Exploration of interictal to ictal transition in epileptic seizures using a neural mass model.Cognitive neurodynamics · 2024Article
- Construction and Analysis of a New Resting-State Whole-Brain Network Model.Brain sciences · 2024Article
- Suppression of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model.Journal of biological physics · 2023Article
- Stimulation to probe, excite, and inhibit the epileptic brain.Epilepsia · 2023Article
- Global dynamics of neural mass models.PLoS computational biology · 2023Article
- Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics.Frontiers in network physiology · 2022Article
- Classification of bursting patterns: A tale of two ducks.PLoS computational biology · 2022Review
- Canard solutions in neural mass models: consequences on critical regimes.Journal of mathematical neuroscience · 2021Article
- Perturbations both trigger and delay seizures due to generic properties of slow-fast relaxation oscillators.PLoS computational biology · 2021Article
- State-Dependent Effective Connectivity in Resting-State fMRI.Frontiers in neural circuits · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Epilepsy is a dynamic and complex neurological disease affecting about 1% of the worldwide population, among which 30% of the patients are drug-resistant. Epilepsy is characterized by recurrent episodes of paroxysmal neural discharges (the so-called seizures), which manifest themselves through a large-amplitude rhythmic activity observed in depth-EEG recordings, in particular in local field potentials (LFPs). The signature characterizing the transition to seizures involves complex oscillatory patterns, which could serve as a marker to prevent seizure initiation by triggering appropriate therapeutic neurostimulation methods. To investigate such protocols, neurophysiological lumped-parameter models at the mesoscopic scale, namely neural mass models, are powerful tools that not only mimic the LFP signals but also give insights on the neural mechanisms related to different stages of seizures. Here, we analyze the multiple time-scale dynamics of a neural mass model and explain the underlying structure of the complex oscillations observed before seizure initiation. We investigate population-specific effects of the stimulation and the dependence of stimulation parameters on synaptic timescales. In particular, we show that intermediate stimulation frequencies (>20 Hz) can abort seizures if the timescale difference is pronounced. Those results have the potential in the design of therapeutic brain stimulation protocols based on the neurophysiological properties of tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.