Evidence map›Paper›PMID 33165982›Full record

ReviewMass spectrometry reviews2022

ADVANCES IN HIGH-RESOLUTION MALDI MASS SPECTROMETRY FOR NEUROBIOLOGY.

Kellen DeLaney, Ashley Phetsanthad, Lingjun Li

Open access · greenAbstract readReview
In one paragraph

Review in Mass spectrometry reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kellen DeLaneyDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, 53706.
Ashley PhetsanthadDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, 53706.
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, 53706.
University of Wisconsin–Madison · US

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
STATE DEPENDENT COORDINATION OF RHYTHMIC NEURAL CIRCUITSR01NS029436 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MICHAEL P NUSBAUM · 1991 to 2026
$7.4M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
In Situ Protein Characterization and Visualization in the Brains of Mouse Models for AutismR56MH110215 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI IKONOMIDOU, HRISSANTHI, LI, LINGJUN · 2017 to 2018
$752k
Mass spectrometry profiling of secreted neuropeptides in the stomatogastric nervous system in response to feedingF31GM126870 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DELANEY, KELLEN L. · 2018 to 2019
$66k
NHLBI NIH HHS T32 HL007936NIDDK NIH HHS R01 DK071801NIGMS NIH HHS F31 GM126870NIGMS NIH HHS T32 GM008505NIMH NIH HHS R56 MH110215NINDS NIH HHS R01 NS029436
6 · The paper itself

Abstract

Research in the field of neurobiology and neurochemistry has seen a rapid expansion in the last several years due to advances in technologies and instrumentation, facilitating the detection of biomolecules critical to the complex signaling of neurons. Part of this growth has been due to the development and implementation of high-resolution Fourier transform (FT) mass spectrometry (MS), as is offered by FT ion cyclotron resonance (FTICR) and Orbitrap mass analyzers, which improves the accuracy of measurements and helps resolve the complex biological mixtures often analyzed in the nervous system. The coupling of matrix-assisted laser desorption/ionization (MALDI) with high-resolution MS has drastically expanded the information that can be obtained with these complex samples. This review discusses notable technical developments in MALDI-FTICR and MALDI-Orbitrap platforms and their applications toward molecules in the nervous system, including sequence elucidation and profiling with de novo sequencing, analysis of post-translational modifications, in situ analysis, key advances in sample preparation and handling, quantitation, and imaging. Notable novel applications are also discussed to highlight key developments critical to advancing our understanding of neurobiology and providing insight into the exciting future of this field. © 2020 John Wiley & Sons Ltd. Mass Spec Rev.

Indexed as

NeurobiologySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationCyclotronsFourier AnalysisSpecimen HandlingFourier transformhigh-resolution accurate massimagingmass spectrometrymatrix-assisted laser desorption/ionizationneuroscience

Identifiers

PMID33165982
PMCPMC8106695
OpenAlexW3100859636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.