Evidence map›Paper›PMID 33165869›Full record

ReviewCurrent topics in microbiology and immunology2021

Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.

Elizabeth A Grego, Alaric C Siddoway, Metin Uz, Luman Liu, John C Christiansen, Kathleen A Ross, Sean M Kelly, Surya K Mallapragada, Michael J Wannemuehler, Balaji Narasimhan

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Elizabeth A GregoDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
Alaric C SiddowayDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
Metin UzDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
Luman LiuDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
John C ChristiansenDepartments of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, 50011, USA.
Kathleen A RossDepartments of Nanovaccine Institute, Iowa State University, Ames, IA, 50011, USA.
Sean M KellyDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
Surya K MallapragadaDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA.
Michael J WannemuehlerDepartments of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, 50011, USA.
Balaji NarasimhanDepartments of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, USA. nbalaji@iastate.edu.
Iowa State University · US

Funding

Universal room temperature stable influenza nanovaccineR01AI141196 · NIAID · IOWA STATE UNIVERSITY · PI NARASIMHAN, BALAJI · 2019 to 2023
$5.6M
Nanovaccine-Mediated Immune Protection Against Influenza VirusR01AI127565 · NIAID · UNIVERSITY OF IOWA · PI LEGGE, KEVIN L, WALDSCHMIDT, THOMAS J · 2017 to 2021
$2.8M
Nanovaccine platforms to combat pancreatic cancerU01CA213862 · NCI · IOWA STATE UNIVERSITY · PI JAIN, MANEESH, NARASIMHAN, BALAJI · 2017 to 2021
$2.7M
Development of a mucosal, polyanhydride-based nanoparticle vaccine for use against RSV infection in the neonateR01HD095880 · NICHD · IOWA STATE UNIVERSITY · PI MCGILL, JODI, SACCO, RANDY E · 2019 to 2022
$2.1M
Enhanced Shelf-life Nanovaccine Formulation for Immunity to Biodefense PathogensR01AI111466 · NIAID · IOWA STATE UNIVERSITY · PI NARASIMHAN, BALAJI · 2014 to 2017
$1.4M
NCI NIH HHS U01 CA213862NIAID NIH HHS R01 AI111466NIAID NIH HHS R01 AI127565NIAID NIH HHS R01 AI141196NICHD NIH HHS R01 HD095880
6 · The paper itself

Abstract

As vaccine formulations have progressed from including live or attenuated strains of pathogenic components for enhanced safety, developing new adjuvants to more effectively generate adaptive immune responses has become necessary. In this context, polymeric nanoparticles have emerged as a promising platform with multiple advantages, including the dual capability of adjuvant and delivery vehicle, administration via multiple routes, induction of rapid and long-lived immunity, greater shelf-life at elevated temperatures, and enhanced patient compliance. This comprehensive review describes advances in nanoparticle-based vaccines (i.e., nanovaccines) with a particular focus on polymeric particles as adjuvants and delivery vehicles. Examples of the nanovaccine approach in respiratory infections, biodefense, and cancer are discussed.

Indexed as

NanoparticlesVaccinesAdjuvants, ImmunologicHumansImmunity, HumoralAdjuvants, ImmunologicVaccines

Identifiers

PMID33165869
PMCPMC8107186
OpenAlexW3099599496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.