Evidence map›Paper›PMID 33165739›Full record

ArticleJournal of molecular neuroscience : MN2021

Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP

Huan Chen, Yan Teng, Zhihao Liu, Fan Geng, Xingmin Chen, Haisong Jiang, Jing Yang, Min Zheng, Ziyan Wang, Lu Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Huan Chen *Institute of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Yan Teng *Institute of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Zhihao LiuSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Fan GengSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Xingmin ChenSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Haisong JiangInstitute of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Jing YangSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Min ZhengSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China.
Ziyan WangSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China. wangzifengshe@163.com.
Lu YangSchool of medicine, University of Electronic Science and Technology of China, Sichuan, 610072, Chengdu, China. lyang@uestc.edu.cn.
University of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an important endogenous growth factor, PDGF-BB can effectively promote neurogenesis, thus is considered as a potential agent for Parkinson's disease (PD) therapy. However, the protective function of PDGF-BB on neuronal cells, especially the molecular mechanism, remains less clear, which is needed to explore before its clinical practice. In this study, we investigated the function and mechanism of PDGF-BB against 1-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumAntioxidantsBecaplerminCell Line, TumorGlycogen Synthase Kinase 3 betaHumansMAP Kinase Signaling SystemMPTP PoisoningNeuronsNeuroprotective AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReactive Oxygen Species1-Methyl-4-phenylpyridiniumAntioxidantsBecaplerminGlycogen Synthase Kinase 3 betaNeuroprotective AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAktCREBERKMPP+Parkinson’s diseasePDGF-BB

Identifiers

PMID33165739
OpenAlexW3101614570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.