Evidence map›Paper›PMID 33165643›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021

Biomechanical properties of the cornea following intravitreal ranibizumab injection.

Sinan Bekmez, Harun Cakmak, Tolga Kocaturk, Fulden Cantas, Sema Dundar

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Sinan BekmezDepartment of Ophthalmology, University of Health Sciences Izmir Dr. Behcet Uz Children's Diseases and Surgery Training and Research Hospital, Izmir, Turkey. sinanbekmez@gmail.com.ORCID http://orcid.org/0000-0002-7849-2717
Harun CakmakDepartment of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Tolga KocaturkDepartment of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Fulden CantasDepartment of Biostatistics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Sema DundarDepartment of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate intraocular pressure (IOP) and corneal biomechanical properties changes after intravitreal ranibizumab injection (IVRI).

methodsOne hundred twenty eyes of 120 patients who underwent IVRI between January and March 2018 in Adnan Menderes University Ophthalmology Clinic were included in study. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured by Ocular Response Analyzer (ORA) by the same specialist preoperatively (preop), postoperative 1st (postop-1st), postoperative 3rd (postop-3rd), and postoperative 24th hours (postop-24th) after single-dose IVRI.

resultsAmong the 120 wet age-related macular degeneration subjects, 58 (48.3%) were female and 62 (51.7%) were male. The mean age was 64.8 ± 10.4 years. Postop-1st hour IOP cc and IOPg measurements were statistically different from all other measurements (p < 0.001). Postop-1st hour CH measurements were statistically different from preop and postop-3rd (p = 0.022 and p = 0.008, respectively).

conclusionAfter intravitreal injection, IOP pressures significantly increased. But, CH and CRF values were significantly decreased. All these changes were temporary.

Indexed as

Angiogenesis InhibitorsCorneaRanibizumabTonometry, OcularAgedBiomechanical PhenomenaElasticityFemaleHumansIntraocular PressureIntravitreal InjectionsMaleMiddle AgedAngiogenesis InhibitorsRanibizumabCorneal biomechanical propertiesIntraocular pressureIntravitreal injectionOcular Response AnalyzerRanibizumab

Identifiers

PMID33165643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.