Evidence map›Paper›PMID 33165619›Full record

ArticleBioscience reports2020

Green nanogold activity in experimental breast carcinoma in vivo.

Awatif A Hendi, Doaa Mohamed El-Nagar, Manal A Awad, Khalid M Ortashi, Reema Abdullah Alnamlah, Nada M Merghani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Awatif A HendiPhysics Department, College of Science, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia.
Doaa Mohamed El-NagarZoology Department, College of Science,King Saud University, Riyadh 11421, Saudi Arabia.
Manal A AwadKing Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.
Khalid M OrtashiDepartment of Chemical Engineering, King Saud University, Riyadh 11421, Saudi Arabia.
Reema Abdullah AlnamlahPhysics Department, College of Science, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia.
Nada M MerghaniCentral Lab and Prince Naif Centre for Heath Science Research, King Saud University,Riyadh 11421, Saudi Arabia.
King Saud University · SAPrincess Nourah bint Abdulrahman University · SAAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the past few years, fabrication of nanoparticles (NPs) has been deployed widely in technologies and many concerns have emerged about the hazardous effect on human health after NPs exposure.

objectiveGreen synthesis of gold NPs (AuNPs) and assessment of their activity in 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer mouse model.

methodsChloroauric acid (HAuCl4) was used in formation of AuNPs with the help of Curcuma longa as aqueous reducing extract and stabilizing agent at room temperature. Formed NPs were characterized with UV-Vis spectrometry, Fourier-transform infrared spectroscopy (FTIR), Zetasizer measurement, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Virgin female albino mice with DMBA-induced breast cancer were treated with formed AuNPs for 5 consecutive days and were dissected after 28 days of the beginning of treatment.

resultsUV-Vis spectrometry showed absorbance maximum peak at 530 nm for formed AuNPs, FTIR confirmed formation of plant extract layer around formed NPs; zetasizer measurement revealed 278.2 nm as an average size of produced NPs; SEM and TEM approved formation of monodisperse spherical AuNPs. Biochemical analysis of untreated breast cancer group revealed marked changes in liver and kidney functions manifested by raised activity levels of alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine. Whereas, the treated group with AuNPs post-breast cancer induction displayed reduction in the activities (of ALT, AST and creatinine), while the BUN activity level was raised. Histopathological examination showed heavy incidence of tumor foci in the breast and lymph nodes belonged to the untreated breast cancer group confirmed with intense response to Ki-67 antibodies. While the treated group with AuNPs post-breast cancer induction showed degenerated tumor foci in the breast and lymph nodes with weak response to Ki-67 antibodies.

conclusionAuNPs were successfully synthesized using HAuCl4 and C. longa extract confirmed their ability to control DMBA-induced breast cancer in virgin female Swiss albino mice.

Indexed as

Green Chemistry TechnologyMetal NanoparticlesNanomedicine9,10-Dimethyl-1,2-benzanthraceneAlanine TransaminaseAnimalsAntineoplastic AgentsAspartate AminotransferasesBlood Urea NitrogenBreast NeoplasmsCell ProliferationChloridesCreatinineCurcumaExcipientsFemale9,10-Dimethyl-1,2-benzanthraceneAlanine TransaminaseAntineoplastic AgentsAspartate AminotransferasesChloridesCreatinineExcipientsGold Compoundsgold tetrachloride, acidPlant Extractsturmeric extractbreast cancerCurcuma longaDMBAGreen synthesisNanoGold

Identifiers

PMID33165619
PMCPMC7689655
OpenAlexW3103490001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.