Evidence map›Paper›PMID 33165551›Full record

ArticleInternational health2020

Recommendations from Thai stakeholders about protecting HIV remission ('cure') trial participants: report from a participatory workshop.

Holly L Peay, Nuchanart Q Ormsby, Gail E Henderson, Thidarat Jupimai, Stuart Rennie, Krittaecho Siripassorn, Kunakorn Kanchawee, Sinéad Isaacson, R Jean Cadigan, Kriste Kuczynski and 1 more

Open access · goldAbstract read
In one paragraph

Article in International health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Spotlight on global health research.International health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Holly L PeayRTI International, Research Triangle Park, USA.
Nuchanart Q OrmsbyUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
Gail E HendersonUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
Thidarat JupimaiCenter of Excellence in Pediatric Infectious Diseases and Vaccines Faculty of Medicine, Chulalongkorn University, Thailand.
Stuart RennieUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
Krittaecho SiripassornBamrasnaradura Infectious Diseases Institute, Thailand.
Kunakorn KanchaweeCenter of Excellence in Research on Gender, Sexuality and Health, Faculty of Social Sciences and Humanities, Mahidol University, Thailand.
Sinéad IsaacsonUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
R Jean CadiganUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
Kriste KuczynskiUniversity of North Carolina at Chapel Hill, Department of Social Medicine, USA.
Udom LikhitwonnawutThailand National CAB on HIV research, Thailand.
University of North Carolina at Chapel Hill · USBamrasnaradura Infectious Diseases Institute · THChulalongkorn University · THHIV Netherlands Australia Thailand Research Collaboration · THMahidol University · THRTI International · US

Funding

Integrating Decision Making Studies into HIV Cure Trials: A real-time longitudinal assessmentR01AI127024 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HENDERSON, GAIL E · 2016 to 2019
$2.2M
NIAID NIH HHS R01 AI127024
6 · The paper itself

Abstract

backgroundThe social/behavioral HIV Decision-Making Study (DMS) assesses informed consent and trial experiences of individuals in HIV remission trials in Thailand. We convened a 1-d multi-stakeholder participatory workshop in Bangkok. We provide a meeting summary and reactions from DMS investigators.

methodsWorkshop members viewed de-identified interview excerpts from DMS participants. They deliberated on the findings and made recommendations regarding informed choice for remission trials. Notes and recordings were used to create a summary report, which was reviewed by members and refined.

resultsWorkshop members' recommendations included HIV education and psychosocial support to establish the basis for informed choice, key trial information to be provided in everyday language, supportive decision-making processes and psychosocial care during and after the trial. Concerns included participant willingness to restart antiretrovirals after trial-mandated treatment interruption, unintended influence of the research team on decision-making and seemingly altruistic motivations for trial participation that may signal attempts to atone for stigmatized behavior.

conclusionsThe workshop highlighted community perspectives and resulted in recommendations for supporting informed choice and psychosocial and physical health. These are the first such recommendations arising from a deliberative process. Although some elements are rooted in the Thai context, most are applicable across remission trials.

Indexed as

Clinical Trials as TopicHIV InfectionsResearch ReportHumansInformed ConsentLanguageThailandcure trialsethicsHIVinformed consentstakeholder engagement

Identifiers

PMID33165551
PMCPMC7650909
OpenAlexW3098622869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.