ArticleInternational journal of clinical and experimental pathology2020
Network pharmacology-based study of the molecular mechanisms of Qixuekang in treating COVID-19 during the recovery period.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Therapeutic effects and molecular mechanisms of isorhamnetin against pulmonary diseases.Inflammopharmacology · 2026Review
- Effectiveness and safety of Qixuekang Oral Liquid on vascular health.Journal of translational internal medicine · 2024Article
- Article
- Thrombocytopenia in COVID‑19 and vaccine‑induced thrombotic thrombocytopenia.International journal of molecular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this research, the analytical method of network pharmacology was used to explore Qixuekang molecular mechanism in treating Coronavirus 2019 (COVID-19) during the recovery period.
methodsTraditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to collect the active components and corresponding targets of Qixuekang. Disease targets, related to COVID-19 during the recovery period, were collected from the GeneCards database. Protein-Protein interaction (PPI) network was built by using the String database, and analyzing and using Cytoscape 3.7.0 software to screen out hub genes. GO enrichment and KEGG pathway enrichment analysis were analyzed by R 3.6.1 software.
results34 active components of Qixuekang were screened out, and 161 common targets of drug and disease were identified. GO enrichment suggested 141 biologic processes, mainly involving nuclear receptor activity, transcription factor activity, and direct ligand regulated sequence-specific DNA binding. KEGG pathway enrichment suggests 96 signaling pathways, mainly including TNF signaling pathway, IL-17 signal pathway, and C-type lectin receptor signal pathway. The hub genes, screened in the PPI network, were mainly inclusive of CXCL8, CXCL2, CXCL10, ADRA2A, and ADRA2C.
conclusionQixuekang has numerous components and targets in treating COVID-19 during the recovery period. It is mainly applied in anti-inflammatory action and regulating immune defense, which may guide clinical trials in the later stage.
Indexed as
Identifiers
33165417PMC7642714W3099797069What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.