Evidence map›Paper›PMID 33165407›Full record

ArticleInternational journal of clinical and experimental pathology2020

Effect of dexmedetomidine on perioperative inflammation and lung protection in elderly patients undergoing radical resection of lung cancer.

Yang Xie, Wenqiang Jiang, Lihong Zhao, Yifan Wu, Hong Xie

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04932746 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Dexmedetomidine on Oxygen and Intrapulmonary Shunt During One Lung Ventilation in Pediatric Surgery: Randomized Controlled Trial

TypeinterventionalSponsorDamascus UniversityRan2021 to 2023Enrolled110ConditionsOne Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, PneumonectomyArmsDexmedetomidine, Placebo
NCT06822088 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery

TypeinterventionalSponsorJinqiao QianRan2025 to 2026Enrolled126ConditionsEsketamine, One-lung Ventilation, Oxygenation IndicesArmsEsketamine, Dexmedetomidine, Normal Saline
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yang XieDepartment of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital Suzhou, Jiangsu Province, China.
Wenqiang JiangDepartment of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital Suzhou, Jiangsu Province, China.
Lihong ZhaoDepartment of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital Suzhou, Jiangsu Province, China.
Yifan WuDepartment of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Municipal Hospital Suzhou, Jiangsu Province, China.
Hong XieDepartment of Anesthesiology and Critical Care, The Second Affiliate Hospital of Soochow University Suzhou, Jiangsu Province, China.
Suzhou Municipal Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of dexmedetomidine on perioperative inflammation and lung protection in elderly patients undergoing thoracoscopic radical resection of lung cancer.

methodsA total of 116 elderly patients undergoing elective radical resection of lung cancer in the Second Affiliate Hospital of Soochow University were selected and divided into two groups by random number table method, 58 cases in each group. Observation group was given 1 μg/kg loading dose of dexmedetomidine by continuously intravenous pump for 10 min before anesthesia induction, which was maintained at a rate of 0.3 μg/(kg·h) until 20 min before the end of operation. Control group was given equal volume of normal saline. Heart rate, mean arterial pressure, and alveolar-arterial oxygen pressure difference (P(A-a)O

resultsCompared with control group, heart rate, P(A-a)O

conclusionDexmedetomidine can reduce inflammatory response and oxidative stress response in elderly patients undergoing radical resection of lung cancer, and reduce the occurrence of postoperative pulmonary complications, thus playing a role in lung protection.

Indexed as

Dexmedetomidineinflammatory responselung protectionoxidative stress responseradical resection of lung cancer

Identifiers

PMID33165407
PMCPMC7642717
OpenAlexW3101892078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.