Evidence map›Paper›PMID 33165354›Full record

ArticleInternational journal of clinical and experimental pathology2020

Protective activity of asatone against ovalbumin-induced allergic asthma.

Jing Wu, Yaqiong Liu, Jun Hu, Jun Xie, Zuqiong Nie, Wanling Yin

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jing WuDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Yaqiong LiuDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Jun HuDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Jun XieDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Zuqiong NieDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Wanling YinDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic asthma is a chronic lung disease characterized by wheezing, coughing, chest tightness and shortness of breath. Clinically, the treatments against asthma focus on controlling the symptoms rather than inhibiting recurrence radically. Additionally, local and systemic side effects caused by current treatments are worthy of attention. Therefore, a novel therapeutic strategy against asthma is needed. Asatone is a pharmacologically active component from Radix et Rhizoma Asari, which has anti-inflammatory effects in lipopolysaccharide-induced lung injury. In the present study, we showed that asatone could protect mice against OVA-induced asthma, as manifested by attenuating inflammation infiltration, mucus production, and airway hyperreactivity and suppressing the elevation of IL-4, IL-5, and IL-13 in broncho-alveolar lavage fluid. Overall, results of the present study support use of asatone as a potent therapeutic strategy for clinical treatment of allergic asthma.

Indexed as

airway hyperreactivityAsatoneasthmaTh2 cells

Identifiers

PMID33165354
PMCPMC7642709
OpenAlexW3100894335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.