ArticleInternational journal of clinical and experimental pathology2020
Mutual activation between cancer-associated fibroblasts and cancer cells facilitates growth and progression of gastric cancer.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.Communications biology · 2026Article
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Authors and funding
7 authors.
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Abstract
objectiveThe study aimed to investigate the mutual interaction between cancer-associated fibroblasts (CAFs) and gastric cancer cells.
methodsCell proliferation was determined using MTT assay. The characteristic proteins of CAFs were examined by immunohistochemistry assay, western blot, and real time-quantitative polymerase chain reaction. The effect of CAFs in promotion of tumor growth and progression was evaluated in gastric tumor-bearing mice.
resultsWe confirmed that CAFs promote proliferation and migration of gastric cancer cells (MKN-45). Co-incubation of normal human fibroblast cells (BJ cells) with MKN-45-conditioned medium resulted in overexpression of biomarkers of CAFs, such as FAP, α-SMA, MMP, GAL-1, PDGFRβ, and VIM. Furthermore, the mice co-implanted with MKN-45 cells and CAFs exhibited the rapidest tumor growth rate and shortest survival time when compared with others. Tumors of mice injected with MKN-45 cells and BJ cells progressed faster than those of mice injected only with MKN-45 cells. Further immunohistochemical assay revealed that tumor tissues of the MKN-45 + CAF group displayed the most obvious vasculature formation, which facilitates tumor progression and metastasis.
conclusionNormal fibroblasts in a tumor microenvironment can be induced into CAFs and in turn promote tumor growth and progression.
Indexed as
Identifiers
33165335PMC7642703What OpenQuestion holds
Registered trials
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