Evidence map›Paper›PMID 33165152›Full record

ReviewThe Journal of head trauma rehabilitation

Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military Populations.

Lindsay M Oberman, Shannon Exley, Noah S Philip, Shan H Siddiqi, Maheen M Adamson, David L Brody

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of head trauma rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Non-invasive brain stimulation and neuroenhancement.Clinical neurophysiology practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsay M ObermanCenter for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland (Dr Oberman); Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Ms Exley); Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island (Dr Philip); Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (Dr Siddiqi); Department of Neurosurgery, Stanford School of Medicine, Stanford, and Department of Rehabilitation, VA Palo Alto Healthcare System, Palo Alto, California (Dr Adamson); and Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, and Brain MRI Molecular Contrast Agent Unit, Laboratory of Molecular and Functional Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Dr Brody).
Shannon Exley
Noah S Philip
Shan H Siddiqi
Maheen M Adamson
David L Brody

Funding

Combined Transcranial Direct Current Stimulation and Virtual Reality for PTSDI01RX002450 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2018 to 2022
–
Pilot Testing of Theta-Burst Neuromodulation for Chronic PTSDI21RX002032 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2016 to 2018
–
RRD VA I01 RX002450RRD VA I21 RX002032
6 · The paper itself

Abstract

backgroundSince the year 2000, over 342 000 military service members have experienced a concussion, often associated with chronic neuropsychiatric and neurocognitive symptoms. Repetitive transcranial magnetic stimulation (rTMS) protocols have been developed for many of these symptoms in the general population.

objectiveTo conduct a scoping review of the literature on rTMS for neuropsychological and neurocognitive symptoms following concussion.

methodsPubMed and Google Scholar search engines identified 9 articles, written in English, corresponding to the search terms TBI or concussion; and TMS or rTMS; and depression, PTSD, or cognition. Studies that were not therapeutic trials or case reports, did not have neuropsychiatric or neurocognitive primary outcome measures, or described samples where 80% or more of the cohort did not have a TBI were excluded.

resultsThere were no reports of seizures nor difference in the frequency or quality of other adverse events as compared with the broader rTMS literature, supporting the safety of rTMS in this population. Support for the efficacy of rTMS for the treatment of neuropsychiatric and neurocognitive symptoms, in this population, is limited.

conclusionsLarge-scale, innovative, neuroscience-informed protocols are recommended to elucidate the potential utility of rTMS for the complex neuropsychiatric and neurocognitive symptoms associated with military concussions.

Indexed as

Brain ConcussionMilitary PersonnelTranscranial Magnetic StimulationCognitionDepressionHumansSeizuresStress Disorders, Post-Traumatic

Identifiers

PMID33165152
PMCPMC7664843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.