Evidence map›Paper›PMID 33164891›Full record

ArticleExperimental gerontology2020

Plasma levels of corticosterone, tumor necrosis factor receptor 1 and interleukin 6 are influenced by age, sex and chronic inflammation in mice treated with acute temperature stress.

Ning Ge, Reyhan Westbrook, Jacqueline Langdon, Huanle Yang, Ruth Marx, Peter Abadir, Qian-Li Xue, Jeremy D Walston

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ning GeDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA; The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Reyhan WestbrookDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Jacqueline LangdonDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Huanle YangDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Ruth MarxDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Peter AbadirDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Qian-Li XueDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA.
Jeremy D WalstonDepartment of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA. Electronic address: jwalston@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USSichuan University · CN

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
NIA NIH HHS P30 AG021334
6 · The paper itself

Abstract

Resiliency is the ability to respond to, adapt to and recover from stressors. Deterioration of resiliency in older adults has been hypothesized to be regulated by age-related changes in stress response systems, including the Hypothalamic Pituitary Adrenal (HPA) axis and the innate immune system response. Although age-related chronic inflammation is strongly related to lack of resiliency, the impact of chronic inflammation on acute stress response is unclear. Here we describe the impact of a five-hour exposure to cold temperature acute stressor, on immune and corticosterone response using older and younger IL-10

Indexed as

CorticosteroneInterleukin-6AgedAnimalsFemaleHumansHypothalamo-Hypophyseal SystemInflammationMicePituitary-Adrenal SystemPlasmaReceptors, Tumor Necrosis Factor, Type IStress, PhysiologicalTemperatureCorticosteroneInterleukin-6Receptors, Tumor Necrosis Factor, Type IAgingChronic inflammationCold stressFrailtyResiliency

Identifiers

PMID33164891
PMCPMC7705815
OpenAlexW3093848282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.