ArticleNeurobiology of aging2021
Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers.
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Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
–field-weighted citation impact
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Who cites it
21 citing papers in PubMed.
- Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- SuperAging is not the inverse of common-variant Alzheimer's risk: evidence across genetic ancestries.Alzheimer's research & therapy · 2026Article
- Genetic analysis of neurodegenerative diseases.The Journal of clinical investigation · 2026Review
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Evaluating polygenic risk score prediction performance for Alzheimer's disease in a population-based Hispanic cohort using single- and multi-ancestry models.Lancet regional health. Americas · 2025Article
- Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer's disease comorbidities.Scientific reports · 2025Article
- Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study.The Australian and New Zealand journal of psychiatry · 2025Article
- Mid-to-Late Life Healthy Lifestyle Modifies Genetic Risk for Longitudinal Cognitive Aging among Asymptomatic Individuals.medRxiv : the preprint server for health sciences · 2024Article
- Association between pre-dementia psychiatric diagnoses and all-cause dementia is independent from polygenic dementia risks in the UK Biobank.EBioMedicine · 2024Article
- Apolipoprotein E moderates the association between non-APOE polygenic risk score for Alzheimer's disease and aging on preclinical cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Pitfalls of predicting age-related traits by polygenic risk scores.Annals of human genetics · 2023Review
- Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease.Molecular psychiatry · 2023Review
- Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes.Human genomics · 2023Article
- Apolipoprotein E moderates the association between Non-medRxiv : the preprint server for health sciences · 2023Article
- Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.Scientific reports · 2023Article
- What does heritability of Alzheimer's disease represent?PloS one · 2023Article
- Transcriptomic profiling of sporadic Alzheimer's disease patients.Molecular brain · 2022Article
- The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.Nature communications · 2022Article
- Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.Translational psychiatry · 2022Article
- Mapping the genetic landscape of early-onset Alzheimer's disease in a cohort of 36 families.Alzheimer's research & therapy · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Brian Fulton-HowardDepartment of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alison M GoateDepartment of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert P AdelsonLitwin-Zucker Center for Alzheimer's Disease, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Jeremy KoppelLitwin-Zucker Center for Alzheimer's Disease, The Feinstein Institutes for Medical Research, Manhasset, NY, USA; Division of Geriatric Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Marc L GordonLitwin-Zucker Center for Alzheimer's Disease, The Feinstein Institutes for Medical Research, Manhasset, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Alzheimer's Disease Genetics ConsortiumUniversity of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Nir BarzilaiInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Gil AtzmonInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA; Faculty of Natural Sciences, University of Haifa, Abba Hushi Boulevard, Mount Carmel, Haifa, Israel.
Peter DaviesLitwin-Zucker Center for Alzheimer's Disease, The Feinstein Institutes for Medical Research, Manhasset, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Yun Freudenberg-HuaLitwin-Zucker Center for Alzheimer's Disease, The Feinstein Institutes for Medical Research, Manhasset, NY, USA; Division of Geriatric Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Electronic address: yfreuden@northwell.edu.
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTHE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3MThe National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2010 to 2024
$10.8MGenome Wide associate analysis of Alzheimer's DiseaseRC2AG036528 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2010
$5.4MGenomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MIdentification and characterization of AD risk networks using multi-dimensional "omics" dataU01AG052411 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2016 to 2020
$4.5MLGP/LongenityR01AG046949 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2013 to 2017
$2.4MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MNIA NIH HHS K08 AG054727NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG046949NIA NIH HHS RC2 AG036528NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG052411NIA NIH HHS U01 AG058635NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIH HHS S10 OD018522NIH HHS S10 OD026880
Abstract
To evaluate how age and apolipoprotein E-ε4 (APOE4) status interact with APOE-independent polygenic risk score (PRS
Indexed as
HeterozygoteAgedAge FactorsAge of OnsetAlzheimer DiseaseApolipoprotein E4FemaleHumansMaleMiddle AgedMultifactorial InheritanceRisk FactorsApolipoprotein E4Alzheimer's diseaseAPOEGenetic risksPolygenic risk scoreRisk interactionsSuperager
Identifiers
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