ArticleeLife2020
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 4 pooled it
12.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
128 citing papers in PubMed, 4 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.Nature genetics · 2023Pooled it
- Gut distress and interventionFrontiers in public health · 2023Pooled it
- Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?Paediatric respiratory reviews · 2022Pooled it
- Single cell meta-analysis of EndMT and EMT state in COVID-19.Frontiers in immunology · 2022Pooled it
- Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases.Nature immunology · 2026Article
- Article
- Mesothelial Plasticity Specifies Divergent Pleural Immune Circuits that Instruct Lung Regeneration versus Degeneration.Research square · 2026Article
- Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.Science advances · 2026Article
- Spatially Resolved Heterogeneity of Lymphatic Vasculature in the Adult Lung-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Lense: Optimizing data preprocessing in single-cell omics using LLMs.bioRxiv : the preprint server for biology · 2026Article
- Lense: optimizing data preprocessing in single-cell omics using large language models.Briefings in bioinformatics · 2026Article
- Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.Cell proliferation · 2026Article
- A generic reference defined by consensus peaks for single-cell ATAC-seq data analysis.Nature communications · 2026Article
- Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.Cell stem cell · 2026Article
- Metabolic reprogramming is associated with symptomatic COVID-19: a serum proteomics and causal inference study identifying ALDOB and glycerol as candidate metabolic correlates.Frontiers in microbiology · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub.Frontiers in cell and developmental biology · 2026Review
- Convergent hub pathways targeted by IAV, SARS-CoV-2, and RSV in type II alveolar epithelial cells: molecular mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Expression of angiotensin-converting enzyme 2, transmembrane serine protease 2, and sirtuin 1 proteins in lungs of different age groups.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2026Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 1 country.
Allen Wang *Center for Epigenomics & Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0001-9870-7888
Joshua Chiou *Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, United States.ORCID 0000-0002-4618-0647
Olivier B Poirion *Center for Epigenomics & Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, United States.
Justin Buchanan *Center for Epigenomics & Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, United States.
Michael J Valdez *Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, United States.
Jamie M VerheydenDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.ORCID 0000-0003-4116-8507
Xiaomeng HouCenter for Epigenomics & Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, United States.
Parul KudtarkarDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Sharvari NarendraDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Jacklyn M NewsomeDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Minzhe GuoDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Dina A FaddahVertex Pharmaceuticals, San Diego, United States.
Kai ZhangLudwig Institute for Cancer Research, La Jolla, United States.
Randee E YoungDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Justinn BarrDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Eniko SajtiDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.
Ravi MisraDepartment of Pediatrics and Clinical & Translational Science Institute, University of Rochester Medical Center, Rochester, United States.
Heidie HuyckDepartment of Pediatrics and Clinical & Translational Science Institute, University of Rochester Medical Center, Rochester, United States.
Lisa RogersDepartment of Pediatrics and Clinical & Translational Science Institute, University of Rochester Medical Center, Rochester, United States.
Cory PooleDepartment of Pediatrics and Clinical & Translational Science Institute, University of Rochester Medical Center, Rochester, United States.
Jeffery A WhitsettDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Gloria PryhuberDepartment of Pediatrics and Clinical & Translational Science Institute, University of Rochester Medical Center, Rochester, United States.
Yan XuDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Kyle J GaultonDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.ORCID 0000-0003-1318-7161
Sebastian PreisslCenter for Epigenomics & Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0001-8971-5616
Xin SunDepartment of Pediatrics, University of California-San Diego, La Jolla, United States.ORCID 0000-0001-8387-4966
NHLBI LungMap ConsortiumNIH, Bethesda, United States.
University of California San Diego · USUniversity of Rochester Medical Center · USCincinnati Children's Hospital Medical Center · USLudwig Cancer Research · USUniversity of Wisconsin–Madison · USVertex Pharmaceuticals (United States) · US
Funding
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5MBioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7MTraining Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6MBiorepository for Investigation of Neonatal Diseases of Lung-Normal (BRINDL-NL)U01HL122700 · NHLBI · UNIVERSITY OF ROCHESTER · PI PRYHUBER, GLORIA S · 2014 to 2018
$6.1MLungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5MDecoding the Cellular Niches Critical for Lung Maturation and PathogenesisU01HL148867 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2019 to 2023
$4.4MUC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6MEpigenomics of mononuclear phagocytes in prematurity associated lung diseaseK08HL140198 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAJTI, ENIKO · 2018 to 2022
$886kNot all those who wander are lost: Specification of lung innervating sensory neuronsF32HL151168 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARR, JUSTINN · 2020 to 2022
$204kHumanTissue Core HL148861HumanTissue Core U01HL122700NCATS NIH HHS UL1 TR002001NHLBI NIH HHS 1U01HL148867NHLBI NIH HHS F32 HL151168NHLBI NIH HHS K08 HL140198NHLBI NIH HHS U01 HL122700NHLBI NIH HHS U01HL122700NHLBI NIH HHS U01 HL148856NHLBI NIH HHS U01 HL148861NHLBI NIH HHS U01 HL148867NIGMS NIH HHS T32 GM007133NIGMS NIH HHS T32 GM008666NIGMS NIH HHS T32 GM145427
Abstract
Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We mapped candidate
Indexed as
AdultAge FactorsAlveolar Epithelial CellsAngiotensin-Converting Enzyme 2Child, PreschoolChromosome MappingCOVID-19Gene Expression ProfilingGenetic VariationHost Microbial InteractionsHumansInfant, NewbornLungMembrane Transport ProteinsPandemicsReceptors, VirusACE2 protein, humanAngiotensin-Converting Enzyme 2Membrane Transport ProteinsReceptors, VirusSLC6A20 protein, humancis-regulatory elementsCOVID-19developmental biologygene regulationgeneticsgenomicshumanhuman sequence variantslungsingle cell RNA/ATAC-seq
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.