Evidence map›Paper›PMID 33164748›Full record

ArticleeLife2020

Repression of interrupted and intact rDNA by the SUMO pathway in

Yicheng Luo, Elena Fefelova, Maria Ninova, Yung-Chia Ariel Chen, Alexei A Aravin

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. piRNA direct the chromatin reader to its genomic targets.bioRxiv : the preprint server for biology · 2026
    Article
  3. AbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Under the magnifying glass: The ups and downs of rDNA copy number.Seminars in cell & developmental biology · 2023
    Review
  10. The homeostatic regulation of ribosome biogenesis.Seminars in cell & developmental biology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Yicheng LuoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-3704-2389
Elena FefelovaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-9185-1243
Maria NinovaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Yung-Chia Ariel ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Alexei A AravinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-6956-8257
California Institute of Technology · US

Funding

Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
Elucidating the role of SUMO ligase Su(var)2-10 in piRNA-guided transcriptional silencing and repressive chromatin formationK99HD099316 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NINOVA, MARIA ANTONINOVA · 2019 to 2020
$259k
Howard Hughes Medical InstituteMinistry of Education and Science of Russian Federation 14.W03.31.0007NICHD NIH HHS K99 HD099316NIGMS NIH HHS R01 GM097363
6 · The paper itself

Abstract

Ribosomal RNAs (rRNAs) are essential components of the ribosome and are among the most abundant macromolecules in the cell. To ensure high rRNA level, eukaryotic genomes contain dozens to hundreds of rDNA genes, however, only a fraction of the rRNA genes seems to be active, while others are transcriptionally silent. We found that individual rDNA genes have high level of cell-to-cell heterogeneity in their expression in

Indexed as

Genes, rRNAAnimalsDNA, RibosomalDNA Transposable ElementsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationHeterochromatinMetabolic Networks and PathwaysModels, GeneticNuclear ProteinsRepressor ProteinsSmall Ubiquitin-Related Modifier ProteinsTransgenesUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9DNA, RibosomalDNA Transposable ElementsDrosophila ProteinsHeterochromatinNuclear ProteinsRepressor ProteinsSmall Ubiquitin-Related Modifier Proteinssmt3 protein, DrosophilaUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9chromosomesdifferential expressionD. melanogasterepigenetic regulationgene expressiongeneticsgenomicsrDNASUMOtransposon

Identifiers

PMID33164748
PMCPMC7676866
OpenAlexW3098682203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.