Evidence map›Paper›PMID 33164617›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2021

The p48 flow diverter: First clinical results in 25 aneurysms in three centers.

Fra Van den Bergh, T De Beule, W J van Rooij, M H Voormolen, T Van der Zijden, L Stockx, W H van Zwam, H Fransen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Patient outcomes after treatment of brain aneurysm in small diameter vessels with the silk vista baby flow diverter: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Early clinical experience with the p48MW HPC and p64MW HPC flow diverters in the anterior circulation aneurysm using single anti-platelet treatment.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Fra Van den BerghDepartment of Radiology, Algemeen Ziekenhuis St Lucas, Gent, Belgium.
T De BeuleDepartment of Radiology, Ziekenhuis Oost-Limburg, Genk, Belgium.ORCID https://orcid.org/0000-0002-2987-5818
W J van RooijDepartment of Radiology, Algemeen Ziekenhuis Turnhout, Turnhout, Belgium.ORCID https://orcid.org/0000-0001-5931-1186
M H VoormolenDepartment of Radiology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium.
T Van der ZijdenDepartment of Radiology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium.
L StockxDepartment of Radiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
W H van ZwamDepartment of Radiology, Maastricht Universiteit Medisch Centrum, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-1631-7056
H FransenDepartment of Radiology, Algemeen Ziekenhuis St Lucas, Gent, Belgium.
Antwerp University Hospital · BEAZ Sint-Lucas · BEZiekenhuis Oost-Limburg · BEAZ Turnhout · BEMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel low-profile p48 flow diverter has been designed to treat aneurysms on small vessels of 1.75-3mm. We report our first clinical experiences.

methodsBetween March 2018-January 2020, 22 patients with 25 aneurysms were treated with the p48 in 3 centers. One patient had 3 aneurysms covered by one p48 and one patient had 2 aneurysms. There were 5 men, 17 women, with a mean age of 55 years (median 59, range 29-73 years).

resultsIn 25 aneurysms, 24 p48 flow diverters were placed. In 1 patient additional coils were placed in the aneurysm. Procedural vessel rupture by the micro guidewire occurred in 2 patients and vessel rupture during p48 balloon dilatation occurred in 1 patient. Overall, the permanent morbidity rate was 13.6% (3 of 22, 95%CI 3.9-34.2%) and mortality was 4.5% (1 of 22, 95%CI <0.01-23.5%). Most complications were procedure-related and not device-specific. Of 22 patients with 25 aneurysms treated with p48, 18 patients with 20 aneurysms had angiographic follow-up after 5-18 months. Of 19 aneurysms, 10 were occluded and 7 showed a remnant. Two aneurysms were open after 6 months. Three aneurysms were still not occluded after 12, 14, and 18 months and these 3 were retreated. Retreatment rate was 16% (3 of 19) and the adequate occlusion rate was 90% (17 of 19).

conclusionsTreatment of aneurysms in small-caliber vessels with the p48 is feasible and effective but is not without complications. More data is needed to establish indications, safety, and efficacy more accurately.

Indexed as

Embolization, TherapeuticEndovascular ProceduresIntracranial AneurysmAdultAgedAngiographyFemaleHumansMaleMiddle AgedRetrospective StudiesStentsTreatment Outcomecomplicationsflow diversionFlow diverterinterventional radiology, p48, p48 MW, endovascular treatmentintracranial aneurysms

Identifiers

PMID33164617
PMCPMC8190948
OpenAlexW3099085191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.