SynthesisJournal of clinical hypertension (Greenwich, Conn.)2020
Nighttime dipping status and risk of cardiovascular events in patients with untreated hypertension: A systematic review and meta-analysis.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Association between ambulatory blood pressure monitoring patterns with cognitive function and risk of dementia: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Controlled-release oral melatonin supplementation for hypertension and nocturnal hypertension: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Nighttime dipping status and risk of cardiovascular events in patients with untreated hypertension: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Blood pressure variability in daily life: comparing individuals with cervical and upper-thoracic spinal cord injury to non-injured controls.Journal of human hypertension · 2026Article
- Association of the Triglyceride-Glucose Index with Ambulatory Blood Pressure Categories and Circadian Blood Pressure Phenotypes in Untreated Adults: A Single-Centre, ABPM-Based Retrospective Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Relationship between medication class and ambulatory blood pressure profile in the chronic renal insufficiency cohort (CRIC) study.Journal of human hypertension · 2026Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Blood pressure determinants of target organ damage among adults with white coat hypertension with a focus on nocturnal hypertension and blood pressure dipping.Journal of human hypertension · 2026Article
- Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson's disease and multiple system atrophy.NPJ Parkinson's disease · 2026Article
- Association between ambulatory blood pressure monitoring parameters and left ventricular hypertrophy in an Ecuadorian population.Frontiers in medicine · 2026Article
- Association Between the Aggregate Index of Systemic Inflammation and Non-Dipper Blood Pressure Pattern in Hypertensive Patients with Type 2 Diabetes Mellitus.Journal of inflammation research · 2026Article
- The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs.Health science reports · 2026Review
- Variable shift work in family medicine residents is associated with a non-dipper pattern and reduced phase angle: possible adaptive blood pressure mechanisms and body composition imbalance.Frontiers in cardiovascular medicine · 2026Article
- Overnight stiffness index from finger photoplethysmography in relation to markers of cardiovascular risk and vascular ageing.Heart and vessels · 2025Article
- Clinic, Ambulatory and Home Blood Pressure Monitoring for Metabolic Syndrome: Time to Change the Definition?Medicina (Kaunas, Lithuania) · 2025Article
- Association Between Pan-Immune-Inflammation Value and Dipper/Non-Dipper Status in Newly Diagnosed Hypertensive Patients.Journal of inflammation research · 2025Article
- Patient-specific multifactorial mortality risk assessment using classification and regression tree analysis in the context of ambulatory blood pressure monitoring.Journal of nephrology · 2025Article
- White coat and masked effects depend on blood pressure level and time of blood pressure measurement.Frontiers in medicine · 2025Article
- Blood Pressure Regulation in Post-COVID POTS: Beyond Sinus Tachycardia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- The predictive risk factors associated with non-dipper profile in patients with type 2 diabetes and hypertension.Medicine and pharmacy reports · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this systematic review and meta-analysis is to determine whether nocturnal blood pressure fall, expressed by dipping patterns according to ambulatory blood pressure monitoring (ABPM), is a risk factor for cardiovascular events (CVEs) in untreated hypertensives. Α thorough systematic literature search at MEDLINE, Embase, Cochrane Library, and gray literature was conducted through March 2020. Two reviewers screened studies and assessed dipping patterns of untreated hypertensives using ABPM with a follow-up >6 months. Newcastle-Ottawa scale was used for risk of bias assessment. We initially identified 463 reports; of which, seven cohort studies were eligible for meta-analysis enrolling 10 438 untreated hypertensives. Untreated patients classified as dippers at baseline (n = 7081) had significant lower risk of CVEs and total mortality compared to non-dippers (n = 3,357) [RR = 0.67, 95% CI (0.49, 0.92); RR = 0.71, 95% CI (0.59, 0.86)]. However, when patients were further classified into four dipping groups, only reverse dippers, yet not extreme dippers or non-dippers, were at increased risk for CVEs compared to dippers [RR = 0.47, 95% CI (0.33, 0.66)]. Likewise, only reverse dippers had a higher stroke risk than dippers [RR = 0.39, 95% CI (0.22, 0.72)]. When compared with the whole group of dippers (including extreme dippers), non-dipping alone (excluding reverse dipping) was not a significant risk factor for CVEs [RR = 0.84, 95% CI (0.61, 1.16)] or total mortality [RR = 0.84, 95% CI (0.61, 1.16); RR = 0.78, 95% CI (0.53, 1.13), respectively]. Untreated hypertensives may benefit more from the evaluation of reverse dipping rather than the non-dipping phenomenon in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.