Evidence map›Paper›PMID 33164165›Full record

ReviewDrug delivery and translational research2021

Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery.

E S T Egito, L Amaral-Machado, E N Alencar, A G Oliveira

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

E S T EgitoFederal University of Rio Grande Do Norte (UFRN), Department of Pharmacy, Dispersed Systems Laboratory (LaSiD), Natal, RN, Brazil. socratesegito@gmail.com.
L Amaral-MachadoFederal University of Rio Grande Do Norte (UFRN), Department of Pharmacy, Dispersed Systems Laboratory (LaSiD), Natal, RN, Brazil.
E N AlencarFederal University of Rio Grande Do Norte (UFRN), Department of Pharmacy, Dispersed Systems Laboratory (LaSiD), Natal, RN, Brazil.
A G OliveiraSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.
Universidade Federal do Rio Grande do Norte · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poorly soluble active pharmaceutical ingredients (APIs) create major problems in drug dosage form formulation resulting in significant delays in drug pharmaceutical screening, impairing the drug dosage form production. Aiming to minimize the use of excipients for increasing drug apparent solubility and, as a result, its bioavailability, exploration of innovative approaches is an earnest need. Microemulsion is an alternative drug delivery system that emerged as a valuable tool to achieve safe formulations for insoluble compounds and to improve their biopharmaceutical properties and pharmacokinetics. This review aims to present the state of the art of microemulsion systems, bringing an overview about their origin and how they can be properly produced and thoroughly characterized by different approaches. Furthermore, comments on regulatory issues regarding stability assessment and toxicity evaluation are discussed. The review concludes with a current opinion on microemulsion systems. The overall objective of this work was to describe all the potentialities of microemulsion systems as a drug carrier for therapeutic purposes, highlighting the unique features of this nanotechnological platform. Display Image.

Indexed as

Drug Delivery SystemsExcipientsBiological AvailabilityEmulsionsSolubilitySurface-Active AgentsEmulsionsExcipientsSurface-Active AgentsCharacterizationMarketed microemulsionsNanomedicinesRegulatory aspectsToxicity

Identifiers

PMID33164165
OpenAlexW3100753499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.